San-Blas G
Instituto Venezolano de Investigaciones Científicas (IVIC), Centro de Microbiología y Biología Celular, Caracas, Venezuela.
Acta Cient Venez. 1995;46(4):221-4.
Dimorphism in pathogenic fungi is reviewed. The phenomenon is divided into four interwoven events: (a) perception of external stimuli by cellular sensors; (b) translation into a biochemical message; (c) alteration of the genomic expression, and (d) structural reorganization towards the morphological change. Experimental evidence is provided. Finally, the possibility that fungal dimorphism may have arisen multiple times throughout evolution, is discussed.
本文综述了致病真菌中的二态性现象。该现象分为四个相互交织的过程:(a) 细胞传感器对外界刺激的感知;(b) 转化为生化信息;(c) 基因组表达的改变;以及 (d) 朝着形态变化的结构重组。文中提供了实验证据。最后,讨论了真菌二态性在整个进化过程中可能多次出现的可能性。