Dzurec L C
School of Nursing, Oregon Health Sciences University, Oregon Institute of Technology Campus, Klamath Falls 97601, USA.
Res Nurs Health. 1997 Oct;20(5):389-98. doi: 10.1002/(sici)1098-240x(199710)20:5<389::aid-nur3>3.0.co;2-k.
Hypothyroidism is a relative state, long associated with fatigue and depression. Individuals may experience thyroid-related symptoms such as fatigue and depression before thyroid indices become abnormal. However, because of clinicians' diverse interpretations of appropriate circumstances for its use, low-dose, 1-thyroxine supplementation often is overlooked as a therapeutic agent for symptom treatment. The purpose of this exploratory, hermeneutic study was to describe euthyroid individuals' experiences of fatigue and depression before and after low-dose 1-thyroxine supplementation. For women participants, the collective influence of fatigue and depression prior to treatment interfered significantly with their day-to-day lives, despite their euthyroid status. For men, the influence of symptoms was far less substantial than for women. In general, participants responded favorably, both physically and emotionally, to low-dose 1-thyroxine supplementation. Furthermore, no participant experienced 1-thyroxine induced hyperthyroidism or untoward side effects attributable to 1-thyroxine. Further study of effects of 1-thyroxine on symptoms is needed.
甲状腺功能减退是一种相对状态，长期以来与疲劳和抑郁相关。在甲状腺指标变得异常之前，个体可能会出现与甲状腺相关的症状，如疲劳和抑郁。然而，由于临床医生对其使用的适当情况有不同的解释，低剂量的左甲状腺素补充剂常常被忽视作为症状治疗的一种治疗药物。这项探索性的诠释学研究的目的是描述甲状腺功能正常的个体在低剂量左甲状腺素补充前后疲劳和抑郁的经历。对于女性参与者，尽管她们甲状腺功能正常，但治疗前疲劳和抑郁的综合影响严重干扰了她们的日常生活。对于男性，症状的影响远不如女性那么大。总体而言，参与者在身体和情感上对低剂量左甲状腺素补充剂反应良好。此外，没有参与者出现左甲状腺素诱发的甲状腺功能亢进或归因于左甲状腺素的不良副作用。需要进一步研究左甲状腺素对症状的影响。
