Günaydin M, Bedir A, Akpolat T, Kuku I, Pekbay A, Esen S, Ozyilkan E, Arik N, Cengiz K
Dept. of Clinical Microbiology, Ondokuz Mayis University, School of Medicine, Samsun, Turkey.
Infection. 1997 Sep-Oct;25(5):307-9. doi: 10.1007/BF01720402.
A possible agent for human non-A-E hepatitis has been identified and named hepatitis G virus (HGV). The aim of this study is to evaluate the prevalence of serum HGV-RNA among hemodialysis patients in our country and the possible correlations of serum HGV-RNA with antibody to hepatitis C virus (anti-HCV), chronic liver dysfunction, number of blood transfusions, serum hepatitis B surface antigen (HBs Ag), duration of hemodialysis therapy, history of renal transplantation and patients' age and sex. Seventy-eight hemodialysis patients and 59 healthy controls were included in the study. Twenty-seven of 78 hemodialysis patients (34.6%) and two of the 59 healthy controls were serum HGV-RNA positive (p < 0.01, x2 = 17.8). There was no significant difference between the HGV-RNA positive and HGV-RNA negative groups regarding mean duration of dialysis therapy, anti-HCV, chronic liver dysfunction, number of blood transfusions, serum HBs Ag, duration of hemodialysis therapy, history of renal transplantation and patients' age and sex. In conclusion, hemodialysis patients carry the risk for HGV infection and transmission routes and clinical significance of HGV infection in these patients remain to be defined.
一种可能导致人类非甲 - 戊型肝炎的病原体已被鉴定出来，并命名为庚型肝炎病毒（HGV）。本研究的目的是评估我国血液透析患者血清HGV - RNA的流行情况，以及血清HGV - RNA与丙型肝炎病毒抗体（抗 - HCV）、慢性肝功能障碍、输血次数、血清乙肝表面抗原（HBs Ag）、血液透析治疗时间、肾移植病史以及患者年龄和性别的可能相关性。本研究纳入了78例血液透析患者和59例健康对照。78例血液透析患者中有27例（34.6%）血清HGV - RNA阳性，59例健康对照中有2例血清HGV - RNA阳性（p < 0.01，x2 = 17.8）。在透析治疗平均时间、抗 - HCV、慢性肝功能障碍、输血次数、血清HBs Ag、血液透析治疗时间、肾移植病史以及患者年龄和性别方面，HGV - RNA阳性组和HGV - RNA阴性组之间没有显著差异。总之，血液透析患者存在HGV感染风险，HGV在这些患者中的传播途径和临床意义仍有待确定。
