庚型肝炎病毒的分子克隆与疾病关联：一种经输血传播的病原体。
Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent.
作者信息
Linnen J, Wages J, Zhang-Keck Z Y, Fry K E, Krawczynski K Z, Alter H, Koonin E, Gallagher M, Alter M, Hadziyannis S, Karayiannis P, Fung K, Nakatsuji Y, Shih J W, Young L, Piatak M, Hoover C, Fernandez J, Chen S, Zou J C, Morris T, Hyams K C, Ismay S, Lifson J D, Hess G, Foung S K, Thomas H, Bradley D, Margolis H, Kim J P
机构信息
Genelabs Technologies, Redwood City, CA 94063, USA.
出版信息
Science. 1996 Jan 26;271(5248):505-8. doi: 10.1126/science.271.5248.505.
An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis. Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.
一种被命名为庚型肝炎病毒（HGV）的RNA病毒，是从一名慢性肝炎患者的血浆中鉴定出来的。从一个免疫反应性互补DNA克隆进行延伸，得到了编码2873个氨基酸的多聚蛋白的完整基因组（9392个核苷酸）。该病毒与GB病毒C（GBV-C）密切相关，与丙型肝炎病毒、GBV-A和GBV-B的关系较远。HGV与急性和慢性肝炎有关。在肝炎患者中检测到持续病毒血症长达9年。该病毒可通过输血传播。它在全球范围内分布，在美国的志愿献血人群中也有存在。
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