House J G, Stiens S A
Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
Arch Phys Med Rehabil. 1997 Oct;78(10):1062-5. doi: 10.1016/s0003-9993(97)90128-3.
To compare the effectiveness of hydrogenated vegetable oil-based bisacodyl (HVB) suppositories, polyethylene glycol-based bisacodyl (PGB) suppositories, and polyethylene glycol-based, glycerine, docusate sodium mini-enemas (TVC) in subjects with upper motor neuron spinal cord lesions.
Prospective randomized double blind. Fifteen subjects received one of 3 HVB and 3 PGB suppositories in randomized sequence for each of six scheduled bowel care sessions. Additionally, 10 subjects received 3 TVC. The analysis used timed events that divided the bowel care sessions into discrete intervals. The analysis also compared digital simulations, incontinence, and quantity of stool. Wilcoxon rank sum tests and paired t tests were used to compare the means of intervals during bowel care initiated by HVB, PGB, and TVC.
(means in minutes and p values): Time to Flatus-HVB, 32; PGB, 15; TVC, 15; p < .026, HVB-PGB; p < .983, PGB-TVC; Flatus to Stool Flow-HVB, 6.7; PGB, 5.5; TVC, 3.9; p < .672, HVB-PGB; p < .068, PGB-TVC; Defecation Period-HVB, 36; PGB, 20; TVC, 17; p < .037, HVB-PGB; p < .479, PGB-TVC; Wait Until Transfer-HVB, 10.9; PGB, 10.7; TVC, 7.4; p < .932, HVB-PGB; p < .043, PGB-TVC; Total Time for the bowel program-HVB, 74.5; PGB, 43; TVC, 37; p < .010, HVB-PGB; p < .458, PGB-TVC; percent incidence of incontinence between bowel care sessions-HVB, .067; PGB, .067; TVC, .033; p < 1.0, HVB-PGB; p < .678, PGB-TVC; amount of stool produced-HVB, 3.30; PGB, 3.49; TVC, 3.38; p < .276, HVB-PGB; p < .630, PGB-TVC; average number of digital stimulations per bowel care procedure-HVB, 4.4; PGB, 4.1; TVC, 3.8; p < .411, HVB-PGB; p < .293, PGB-TVC; time per digital stimulation in seconds-HVB, 107; PGB, 40; TVC, 83; p < .149, HVB-PGB; p < .352, PGB-TVC; and the total time, in minutes, spent performing digital stimulations during bowel care-HVB, 10.0; PGB, 2.7; TVC, 5.9; p < .151, HVB-PGB; p < .325, PGB-TVC.
Bowel care took less time when initiated with the PGB bisacodyl suppository or TVC mini-enema as compared with the HVB bisacodyl suppository (p < .01).
比较氢化植物油基比沙可啶（HVB）栓剂、聚乙二醇基比沙可啶（PGB）栓剂和聚乙二醇基、甘油、多库酯钠小型灌肠剂（TVC）在上运动神经元脊髓损伤患者中的有效性。
前瞻性随机双盲。15名受试者在6次预定的肠道护理疗程中，随机顺序接受3种HVB栓剂和3种PGB栓剂中的一种。此外，10名受试者接受3次TVC。分析使用定时事件，将肠道护理疗程划分为离散的时间段。分析还比较了指诊模拟、失禁情况和粪便量。采用Wilcoxon秩和检验和配对t检验比较HVB、PGB和TVC启动肠道护理期间各时间段的平均值。
（以分钟为单位的均值和p值）：排气时间-HVB为32分钟；PGB为15分钟；TVC为15分钟；p <.026，HVB与PGB比较；p <.983，PGB与TVC比较；排气至粪便排出时间-HVB为6.7分钟；PGB为5.5分钟；TVC为3.9分钟；p <.672，HVB与PGB比较；p <.068，PGB与TVC比较；排便期-HVB为36分钟；PGB为20分钟；TVC为17分钟；p <.037，HVB与PGB比较；p <.479，PGB与TVC比较；等待转移时间-HVB为10.9分钟；PGB为10.7分钟；TVC为7.4分钟；p <.932，HVB与PGB比较；p <.043，PGB与TVC比较；肠道护理总时间-HVB为74.5分钟；PGB为43分钟；TVC为37分钟；p <.010，HVB与PGB比较；p <.458，PGB与TVC比较；肠道护理疗程间失禁发生率-HVB为.067；PGB为.067；TVC为.033；p < 1.0，HVB与PGB比较；p <.678，PGB与TVC比较；粪便产生量-HVB为3.30；PGB为3.49；TVC为3.38；p <.276，HVB与PGB比较；p <.630，PGB与TVC比较；每次肠道护理程序指诊刺激的平均次数-HVB为4.4次；PGB为4.1次；TVC为3.8次；p <.411，HVB与PGB比较；p <.293，PGB与TVC比较；每次指诊刺激的时间（秒）-HVB为107秒；PGB为40秒；TVC为83秒；p <.149，HVB与PGB比较；p <.352，PGB与TVC比较；以及肠道护理期间进行指诊刺激所花费的总时间（分钟）-HVB为10.0分钟；PGB为2.7分钟；TVC为5.9分钟；p <.151，HVB与PGB比较；p <.325，PGB与TVC比较。
与HVB比沙可啶栓剂相比，使用PGB比沙可啶栓剂或TVC小型灌肠剂启动肠道护理所需时间更短（p <.01）。
