Stiens S A, Luttrel W, Binard J E
VA Puget Sound Health Care System, Department of Rehabilitation Medicine, University of Washington, Seattle 98195, USA.
Spinal Cord. 1998 Nov;36(11):777-81. doi: 10.1038/sj.sc.3100702.
Neurogenic bowel dysfunction resulting from spinal cord injury (SCI) frequently requires bowel care (BC) with stimulant suppositories for initiation of effective defecation. The excessive time required for BC and bowel complications have limited quality of life after SCI.
To test the hypothesis that: the time required for bowel care with bisacodyl suppositories can be reduced by substituting a polyethylene glycol base (PGB) for the traditional hydrogenated vegetable oil base (HVB) in the suppository.
Inpatient SCI medicine unit.
Fourteen persons with SCI with chronic stable paralysis from upper motor neuron SCI for greater than one year with a stable HVB bisacodyl suppository initiated BC.
Crossover Controlled.
Subjects received HVB bisacodyl suppositories for six sequential BC sessions and then were crossed over to PGB bisacodyl suppositories for six more BCs.
BC event times were utilized to derive BC intervals: suppository insertion to first flatus= Time to flatus, first flatus until the beginning of stool flow = Flatus to stool flow, begin stool flow until end stool flow = Defecation period, end stool flow until end of clean up = Clean up, and suppository insertion until end clean up = Total bowel care time.
The data included two groups of BC sessions: HVB (n = 84) and PGB (n = 81). Mean times in minutes and P values from t tests for paired samples yielded: Time to flatus: (HVB 31, PGB 12.8 P < 0.002), Defecation period: (HVB 58, PGB 32, P < 0.0005), Clean up: (HVB 1.9, PGB 3.2 P = 0.165), Total bowel care time: (HVB 102, PGB 51.2 P < 0.0005).
This analysis suggests that PGB based bisacodyl suppositories may stimulate reflex defecation sooner and shorten the Total BC Time as compared with HVB bisacodyl suppositories.
脊髓损伤（SCI）导致的神经源性肠道功能障碍通常需要使用刺激性栓剂进行肠道护理（BC）以启动有效的排便。肠道护理所需的时间过长以及肠道并发症限制了脊髓损伤后的生活质量。
检验以下假设：通过在栓剂中用聚乙二醇基质（PGB）替代传统的氢化植物油基质（HVB），可以减少使用比沙可啶栓剂进行肠道护理所需的时间。
住院脊髓损伤医学科。
14名因上运动神经元脊髓损伤导致慢性稳定瘫痪超过一年且已开始使用稳定的HVB比沙可啶栓剂进行肠道护理的脊髓损伤患者。
交叉对照。
受试者连续接受6次使用HVB比沙可啶栓剂的肠道护理，然后交叉接受另外6次使用PGB比沙可啶栓剂的肠道护理。
利用肠道护理事件时间得出肠道护理间隔时间：栓剂插入至首次排气=排气时间，首次排气至开始排便=排气至排便时间，开始排便至排便结束=排便期，排便结束至清理结束=清理时间，栓剂插入至清理结束=总肠道护理时间。
数据包括两组肠道护理：HVB组（n = 84）和PGB组（n = 81）。配对样本t检验得出的以分钟为单位的平均时间和P值为：排气时间：（HVB组31分钟，PGB组12.8分钟，P < 0.002），排便期：（HVB组58分钟，PGB组32分钟，P < 0.0005），清理时间：（HVB组1.9分钟，PGB组3.2分钟，P = 0.165），总肠道护理时间：（HVB组102分钟，PGB组51.2分钟，P < 0.0005）。
该分析表明，与HVB比沙可啶栓剂相比，基于PGB的比沙可啶栓剂可能更快地刺激反射性排便并缩短总肠道护理时间。
