Ashby J, Lefevre P A, Odum J, Tinwell H, Kennedy S J, Beresford N, Sumpter J P
Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire, United Kingdom.
Regul Toxicol Pharmacol. 1997 Aug;26(1 Pt 1):96-101. doi: 10.1006/rtph.1997.1158.
Earlier reports that benzoic acid is uterotrophic to the rat and mouse and that clofibrate is uterotrophic to the rat have not been confirmed. The studies reported here involved the use of a range of test protocols and dose levels, including the protocols/dose levels used by the original investigators. In addition, both chemicals were inactive in a human estrogen receptor (hER alpha) yeast estrogenicity assay. It is concluded that benzoic acid and clofibrate are not estrogenic in the assays used here. This conclusion has implications for the compilation of lists of endocrine-disrupting chemicals.
早期有报道称苯甲酸对大鼠和小鼠具有子宫营养作用，氯贝丁酯对大鼠具有子宫营养作用，但这些报道尚未得到证实。此处报告的研究涉及使用一系列试验方案和剂量水平，包括原始研究者使用的方案/剂量水平。此外，这两种化学物质在人雌激素受体（hERα）酵母雌激素活性测定中均无活性。结论是，在此处使用的试验中，苯甲酸和氯贝丁酯不具有雌激素活性。这一结论对内分泌干扰化学物质清单的编制具有重要意义。
