Ozagar A, Koç A, Ciprut A, Tutkun A, Akdaş F, Sehitoğlu M A
Department of ENT, Faculty of Medicine, Marmara University, Istanbul, Turkey.
Otolaryngol Head Neck Surg. 1997 Oct;117(4):405-8. doi: 10.1016/S0194-5998(97)70134-7.
Most of the topical otic preparations have been shown to cause ototoxicity. In this study ciprofloxacin hydrochloride, a relatively new topical agent, and gentamicin sulfate were studied in two groups of 20 patients with chronic otitis media. Patients were randomly selected to receive either ciprofloxacin (200 microg/ml) or gentamicin sulfate (5 mg/ml) locally, five drops three times a day for 10 days. Clinical response was seen in 20 of 20 patients in the ciprofloxacin group compared with 6 of 20 patients in the gentamicin group. Audiometric evaluation revealed no significant ototoxic effect in either group. In fact, hearing thresholds were slightly better than pretreatment levels in both groups.
