Esposito S, Noviello S, D'Errico G, Montanaro C
Institute of Infectious Diseases, University of Naples, Ospedale Gesù e Maria, Italy.
Arch Otolaryngol Head Neck Surg. 1992 Aug;118(8):842-4. doi: 10.1001/archotol.1992.01880080064014.
Clinical and bacteriological efficacy of topical ciprofloxacin hydrochloride was compared with that of intramuscular gentamicin sulfate in two groups composed of 30 patients each, all of whom were affected by chronic otitis media in the acute stage. Antibiotics were randomly given for 5 to 10 days according to the following schedules: ciprofloxacin hydrochloride, four drops (250 mg/mL in saline solution) administered locally twice a day, or gentamicin sulfate, 80 mg administered intramuscularly twice a day. We admitted to the study only adult patients affected by chronic otitis media in the acute stage with perforation of the tympanic membrane, without cholesteatoma, whose bacteriological culture was positive for Pseudomonas susceptible in vitro to ciprofloxacin and gentamicin. The clinical and bacteriological response was stated 12 hours after the interruption of the treatment, and 2 and 3 weeks later (follow-up). A favorable clinical result was observed in 26 (87%) of 30 patients under ciprofloxacin treatment; in 30 patients receiving gentamicin, a favorable clinical response was observed in 20 (66%) and bacteriological eradication in 13 (43%). No relapse at the follow-up was observed. Topical ciprofloxacin seems to be more effective than intramuscular gentamicin in curing Pseudomonas-caused chronic otitis media in the acute stage.
将30名患者分为两组，比较局部使用盐酸环丙沙星与肌肉注射硫酸庆大霉素的临床和细菌学疗效，所有患者均为慢性中耳炎急性期患者。根据以下方案随机给予抗生素5至10天：盐酸环丙沙星，局部滴注4滴（盐溶液中浓度为250mg/mL），每日2次；或硫酸庆大霉素，肌肉注射80mg，每日2次。本研究仅纳入慢性中耳炎急性期鼓膜穿孔、无胆脂瘤且细菌学培养显示体外对环丙沙星和庆大霉素敏感的铜绿假单胞菌阳性的成年患者。治疗中断12小时后以及2周和3周后（随访）记录临床和细菌学反应。接受环丙沙星治疗的30例患者中有26例（87%）观察到良好的临床结果；接受庆大霉素治疗的30例患者中，20例（66%）观察到良好的临床反应，13例（43%）细菌学清除。随访未观察到复发。局部使用环丙沙星在治疗铜绿假单胞菌引起的慢性中耳炎急性期似乎比肌肉注射庆大霉素更有效。
