Fradis M, Brodsky A, Ben-David J, Srugo I, Larboni J, Podoshin L
Department of Otolaryngology-Head and Neck Surgery, Bnai Zion Medical Center; and The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Arch Otolaryngol Head Neck Surg. 1997 Oct;123(10):1057-60. doi: 10.1001/archotol.1997.01900100031003.
To evaluate the efficacy of ciprofloxacin compared with tobramycin and placebo ear drops in the treatment of chronic suppurative otitis media without cholesteatoma.
Sixty ears (in 51 patients) were randomly divided into 3 treatment groups: ciprofloxacin hydrochloride, tobramycin, and placebo interventions.
The otolaryngology department of a university teaching hospital.
All ears were treated topically for 3 weeks.
Each patient received a small, numbered bottle and was instructed to instill 5 drops 3 times daily for 3 weeks. The final clinical and bacteriologic assessment was made after 3 weeks.
The organism most commonly isolated from the ear discharge was Pseudomonas aeruginosa. Its sensitivity to ciprofloxacin and tobramycin was 94.2% and 70.6%, respectively. The clinical response was 78.9%, 72.2%, and 41.2% in the ciprofloxacin, tobramycin, and placebo groups, respectively. The bacteriologic response rate was 66.7% for the ciprofloxacin and tobramycin groups and 20% for the placebo group. Treatment with ciprofloxacin ear drops seemed to be as effective as treatment with tobramycin.
While the lack of ototoxicity of ciprofloxacin was not tested in our study, this treatment may be considered as a potential topical therapy for cases of chronic suppurative otitis media.
评估环丙沙星与妥布霉素及安慰剂耳滴剂治疗非胆脂瘤型慢性化脓性中耳炎的疗效。
60只耳（51例患者）被随机分为3个治疗组：盐酸环丙沙星、妥布霉素及安慰剂干预组。
一所大学教学医院的耳鼻喉科。
所有耳均进行局部治疗3周。
每位患者收到一个编有号码的小瓶，并被指示每天滴注5滴，共3周。3周后进行最终的临床和细菌学评估。
从耳分泌物中最常分离出的病原体是铜绿假单胞菌。其对环丙沙星和妥布霉素的敏感性分别为94.2%和70.6%。环丙沙星组、妥布霉素组和安慰剂组的临床有效率分别为78.9%、72.2%和41.2%。环丙沙星组和妥布霉素组的细菌学有效率为66.7%，安慰剂组为20%。环丙沙星耳滴剂治疗似乎与妥布霉素治疗效果相同。
虽然在我们的研究中未测试环丙沙星的耳毒性，但这种治疗可被视为非胆脂瘤型慢性化脓性中耳炎病例的一种潜在局部治疗方法。
