亚硝基胍对体外DNA合成的影响。
The effect of nitrosoguanidine upon DNA synthesis in vitro.
作者信息
Jiménez-Sánchez A
出版信息
Mol Gen Genet. 1976 May 7;145(2):113-7. doi: 10.1007/BF00269582.
PMID:934048
Abstract
Both the polymerase and the exonuclease activities of DNA polymerase III are inactivated by treatment with nitrosoguanidine. The treatment of the DNA template with the mutagen does not affect the template in supporting DNA synthesis. No effect of nitrosoguanidine upon fidelity of replication in vitro was detected.
摘要
用亚硝基胍处理会使DNA聚合酶III的聚合酶活性和核酸外切酶活性均失活。用诱变剂处理DNA模板并不影响其支持DNA合成的能力。未检测到亚硝基胍对体外复制保真度有影响。
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