Furumoto H, Nakamura K, Imamura T, Hamamoto Y, Shimizu T, Muto M, Asagami C
Department of Dermatology, Yamaguchi University School of Medicine, Japan.
Arch Dermatol Res. 1997 Aug;289(9):497-500. doi: 10.1007/s004030050229.
We studied phenotypic variations of apolipoprotein E (apoE) and the corresponding allele frequencies in 100 Japanese patients with psoriasis vulgaris (PV). The phenotypes of apoE were examined using analytical isoelectric focusing followed by immunoblotting with goat anti-apoE antibody and alkaline phosphatase-conjugated rabbit antigoat IgG. The phenotypic frequency of apoE3/2 in PV was significantly higher than in healthy controls, and this elevation was associated with an increased frequency of the epsilon 2 allele. Therefore, it is suggested that the apoE molecule plays an important role in the development of PV.
我们研究了100例寻常型银屑病（PV）日本患者载脂蛋白E（apoE）的表型变异及相应的等位基因频率。采用分析等电聚焦法检测apoE的表型，随后用山羊抗apoE抗体和碱性磷酸酶标记的兔抗山羊IgG进行免疫印迹。PV患者中apoE3/2的表型频率显著高于健康对照，且这种升高与ε2等位基因频率增加有关。因此，提示apoE分子在PV的发病中起重要作用。
