Koenig R J, Peterson C M, Jones R L, Saudek C, Lehrman M, Cerami A
N Engl J Med. 1976 Aug 19;295(8):417-20. doi: 10.1056/NEJM197608192950804.
We studied the increased levels of hemoglobins AIa+Ib and AIc in five hospitalized diabetic patients to determine whether changes in diabetic control would cause parallel changes in the levels of these hemoglobins. Before control of diabetes the mean fasting blood sugar for all patients was 343 mg per deciliter (range, 280 to 450), and hemoglobin AIc concentration 9.8 per cent (range, 6.8 to 12.1). During optimal diabetic control the blood sugar concentration was 84 mg per deciliter (range, 70 to 100), and hemoglobin AIc concentration 5.8 per cent (range, 4.2 to 7.6). Hemoglobin AIc concentration appears to reflect the mean blood sugar concentration best over previous weeks to months. The periodic monitoring of hemoglobin AIc levels provides a useful way of documenting the degree of control of glucose metabolism in diabetic patients and provides a means whereby the relation of carbohydrate control to the development of sequelae can be assessed.
我们研究了5名住院糖尿病患者血红蛋白AIa+Ib和AIc水平的升高情况，以确定糖尿病控制的变化是否会导致这些血红蛋白水平的平行变化。在糖尿病得到控制之前，所有患者的平均空腹血糖为每分升343毫克（范围为280至450），血红蛋白AIc浓度为9.8%（范围为6.8至12.1）。在最佳糖尿病控制期间，血糖浓度为每分升84毫克（范围为70至100），血红蛋白AIc浓度为5.8%（范围为4.2至7.6）。血红蛋白AIc浓度似乎能最好地反映过去数周至数月的平均血糖浓度。定期监测血红蛋白AIc水平为记录糖尿病患者葡萄糖代谢的控制程度提供了一种有用的方法，并提供了一种手段，通过该手段可以评估碳水化合物控制与后遗症发生之间的关系。
