Ditzel J, Kjaergaard J J
Br Med J. 1978 Mar 25;1(6115):741-2. doi: 10.1136/bmj.1.6115.741.
Glycosylated haemoglobins AIa+Ib and AIc were measured serially in 10 consecutive cases of newly discovered non-acidotic diabetes before and after diet and insulin treatment. The average concentration of Hb AIc was 11.4% in untreated diabetics as compared with 4.3% in healthy controls. With prolonged optimal regulation of blood glucose Hb AIc slowly decreased to a mean concentration of 5.5%. The concentration of Hb AIc was significantly correlated with the fasting blood sugar value. The findings suggest that determining Hb AIc may give valuable information on the regulation of carbohydrate metabolism in the preceding one to two months and thus become an important aid to management.
对10例新发现的非酸中毒型糖尿病患者在饮食和胰岛素治疗前后连续测定糖化血红蛋白AIa + Ib和AIc。未经治疗的糖尿病患者中Hb AIc的平均浓度为11.4%，而健康对照组为4.3%。随着血糖的长期最佳调节，Hb AIc缓慢下降至平均浓度5.5%。Hb AIc的浓度与空腹血糖值显著相关。研究结果表明，测定Hb AIc可能为前一至两个月的碳水化合物代谢调节提供有价值的信息，从而成为管理的重要辅助手段。
