Rhodus N L, Bloomquist C, Liljemark W, Bereuter J
Division of Oral Medicine, Minnesota Clinical Dental Research Center, University of Minnesota, Minneapolis, USA.
J Otolaryngol. 1997 Oct;26(5):300-5.
Various investigators have reported a high prevalence of oral Candida species in patients with salivary gland dysfunction (SGD). The purpose of this study was to assess the prevalence of oral Candida albicans, its oral manifestations, and to compare the number of colony-forming units of Candida albicans in patients with primary Sjögren's syndrome and secondary Sjögren's syndrome with the whole unstimulated salivary flow rate in each group.
An age-sex-matched group of control subjects was selected for comparison. Oropharyngeal collection of samples and culturing was performed on each subject. Quantitative cultures specific for Candida albicans were performed.
The frequency distribution indicated that > 80% of all SS subjects were positive for Candida albicans vs. none of the controls. The most common lesion was angular cheilitis followed by chronic atrophic candidiasis. The subjects with Sjögren's syndrome also demonstrated significantly high numbers of Candida albicans colony-forming units.
This study indicates significantly higher Candida albicans colonization in patients with primary or secondary Sjögren's syndrome as compared to a control population. Candida albicans colonization was higher in patients with secondary Sjögren's syndrome than in patients with primary Sjögren's syndrome; however, the amount of Candida albicans was not universally relative to salivary flow.
多位研究者报告称，唾液腺功能障碍（SGD）患者口腔念珠菌属的患病率很高。本研究的目的是评估口腔白色念珠菌的患病率、其口腔表现，并比较原发性干燥综合征和继发性干燥综合征患者白色念珠菌的菌落形成单位数量与每组未刺激唾液流速。
选择一组年龄和性别匹配的对照受试者进行比较。对每个受试者进行口咽样本采集和培养。进行针对白色念珠菌的定量培养。
频率分布表明，所有干燥综合征（SS）受试者中>80%白色念珠菌呈阳性，而对照组均为阴性。最常见的病变是口角炎，其次是慢性萎缩性念珠菌病。干燥综合征患者的白色念珠菌菌落形成单位数量也显著较高。
本研究表明，与对照人群相比，原发性或继发性干燥综合征患者白色念珠菌定植明显更高。继发性干燥综合征患者的白色念珠菌定植高于原发性干燥综合征患者；然而，白色念珠菌的数量与唾液流速并非普遍相关。
