干燥综合征患者口腔念珠菌水平的评估。

Evaluation of the levels of oral Candida in patients with Sjögren's syndrome.

作者信息

Abraham C M, al-Hashimi I, Haghighat N

机构信息

Baylor College of Dentistry, Dallas, Tex., USA.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Jul;86(1):65-8. doi: 10.1016/s1079-2104(98)90151-2.

DOI:10.1016/s1079-2104(98)90151-2

PMID:9690247

Abstract

OBJECTIVE

The purpose of this study was to investigate the levels of oral Candida in patients with Sjögren's syndrome

METHODS

The Candida count and salivary flow rate of patients with Sjögren's syndrome were compared with those of healthy control subjects. Candida cultures were obtained from oral rinses. The numbers of colony-forming units were determined through use of the Spiral System.

RESULTS

The mean Candida count of patients with Sjögren's syndrome was 1672 +/- 1455 colony-forming units per mL; the count of healthy control subjects was 0.00 colony-forming units per mL. The mean salivary flow rate of patients with Sjögren's syndrome was significantly lower than that of healthy control subjects (0.16 +/- 0.13 mL/min/gland vs 0.55 +/- 0.24 mL/min/gland, respectively; p = 0.0001). However, Spearman rank correlation analyses did not reveal a significant correlation between salivary flow rate and Candida count (in colony-forming units per mL) among patients with Sjögren's syndrome.

CONCLUSIONS

Alteration in the oral microbial flora in patients with Sjögren's syndrome may be enhanced by the reduction in salivary output.

摘要

目的

本研究旨在调查干燥综合征患者口腔念珠菌的水平。

方法

将干燥综合征患者的念珠菌计数和唾液流速与健康对照者进行比较。念珠菌培养取自口腔冲洗液。通过使用螺旋系统确定菌落形成单位的数量。

结果

干燥综合征患者的平均念珠菌计数为每毫升1672±1455个菌落形成单位；健康对照者的计数为每毫升0个菌落形成单位。干燥综合征患者的平均唾液流速显著低于健康对照者（分别为0.16±0.13毫升/分钟/腺体和0.55±0.24毫升/分钟/腺体；p = 0.0001）。然而，Spearman等级相关分析未显示干燥综合征患者唾液流速与念珠菌计数（每毫升菌落形成单位）之间存在显著相关性。