Becker J T, Sanchez J, Dew M A, Lopez O L, Dorst S K, Banks G
Department of Psychiatry, University of Pittsburgh Medical Center, Pennsylvania, USA.
Neuropsychology. 1997 Oct;11(4):592-601. doi: 10.1037//0894-4105.11.4.592.
The purpose of this study was to determine the nature and extent of neuropsychological abnormalities among HIV-infected individuals and to examine the interrelationships between measures of cognitive functions and the factors that predict neuropsychological abnormalities. The study focused on cross-sectional data gathered in a multidisciplinary research clinic form 200 HIV-infected (HIV +) men and women recruited from primary medical care settings. Composite scores representing six cognitive domains were derived from the neuropsychological test data. Scores of memory, fluency, spatial, and frontal functions could be predicted by independent assessment of participants' verbal and psychomotor speed abilities. Basic verbal ability itself was predicted by education, race, and handedness, whereas speed was predicted by age, CD4+ cell counts, and a lifetime history of major depression. This model of effects is consistent with the hypothesis that psychomotor slowing is central to mild cognitive disorder in HIV infection and that such changes are associated with markers of the severity of systemic infection.
本研究的目的是确定HIV感染者神经心理异常的性质和程度，并检验认知功能测量指标与预测神经心理异常的因素之间的相互关系。该研究聚焦于从初级医疗保健机构招募的200名HIV感染（HIV+）男性和女性在多学科研究诊所收集的横断面数据。代表六个认知领域的综合分数来自神经心理测试数据。记忆、流畅性、空间和额叶功能的分数可通过对参与者言语和心理运动速度能力的独立评估来预测。基本言语能力本身由教育程度、种族和利手预测，而速度由年龄、CD4+细胞计数和重度抑郁的终生病史预测。这种效应模型与以下假设一致，即心理运动减慢是HIV感染中轻度认知障碍的核心，且此类变化与全身感染严重程度的标志物相关。
