Perry S, Belsky-Barr D, Barr W B, Jacobsberg L
Department of Psychiatry, New York Hospital-Cornell University Medical College, New York.
J Neuropsychiatry Clin Neurosci. 1989 Summer;1(3):296-302. doi: 10.1176/jnp.1.3.296.
Twenty asymptomatic, HIV-seropositive homosexual men and a control group of 20 seronegative homosexual men were evaluated for evidence of neuropsychological impairment. Two-tailed paired t-tests of group differences revealed that the seropositive patients had significantly lower scores on two of 20 neuropsychological measures. Ten seropositive patients had scores two standard deviations below the sample, compared with three seronegative patients, a significantly different distribution (p = .04). The HIV-infected group exhibited lower mean scores on 17 of 20 variables (binomial probability, p less than .005). The 10 seropositive patients with scores that fell below the cut-off had significantly lower mean T4/T8 ratios than the 10 seropositive patients with scores above the cut-off (p = .02). The data suggest that a subpopulation of HIV-infected adults may exhibit subtle neuropsychological impairment before they develop clinical signs of cognitive deficit or immunosuppression.
对20名无症状的HIV血清阳性同性恋男性和20名血清阴性同性恋男性组成的对照组进行了神经心理学损伤证据的评估。两组差异的双尾配对t检验显示，血清阳性患者在20项神经心理学测量中的两项得分显著较低。10名血清阳性患者的得分比样本低两个标准差，而血清阴性患者有3名，分布有显著差异（p = 0.04）。HIV感染组在20个变量中的17个变量上表现出较低的平均得分（二项式概率，p小于0.005）。得分低于临界值的10名血清阳性患者的平均T4/T8比值显著低于得分高于临界值的10名血清阳性患者（p = 0.02）。数据表明，一部分HIV感染的成年人在出现认知缺陷或免疫抑制的临床症状之前，可能会表现出轻微的神经心理学损伤。
