Stratta P, Mancini F, Mattei P, Daneluzzo E, Casacchia M, Rossi A
Department of Psychiatry, S. Salvatore Hospital, L'Aquila, Italy.
Biol Psychiatry. 1997 Nov 1;42(9):816-20. doi: 10.1016/s0006-3223(97)00017-6.
Several findings support the hypothesis that the striatum is implicated in executive functions and in the modulation of goal-directed behavior, and could play a key role in the pathophysiology and in the production of symptoms and signs in schizophrenia. We have studied the relationship between the objective measures of the striatal structures, as evaluated by magnetic resonance imaging (MRI), and the Wisconsin Card Sorting Test (WCST) performance in a schizophrenic sample. Thirty-five schizophrenic patients underwent MRI scans of striatal structure and neuropsychological evaluation of executive functions by WCST. Poor WCST performers had a reduction of the left caudate nucleus and putamen, and right total striatum when compared to 24 healthy controls. Significant correlation coefficients were also observed between neuropsychological indexes and left striatal measures. The findings suggest the existence of a relationship between abnormalities of striatal structure and abnormal executive-type or organizational cognitive functions.
多项研究结果支持这样一种假说，即纹状体与执行功能以及目标导向行为的调节有关，并且可能在精神分裂症的病理生理学以及症状和体征的产生中起关键作用。我们研究了通过磁共振成像（MRI）评估的纹状体结构客观测量值与精神分裂症样本中威斯康星卡片分类测验（WCST）表现之间的关系。35名精神分裂症患者接受了纹状体结构的MRI扫描，并通过WCST进行了执行功能的神经心理学评估。与24名健康对照相比，WCST表现较差的患者左尾状核和壳核以及右侧总纹状体体积减小。在神经心理学指标与左侧纹状体测量值之间也观察到显著的相关系数。这些发现表明纹状体结构异常与异常的执行型或组织性认知功能之间存在关联。
