Cosgrove J F, Neuburger N, Levison H
Pediatrics. 1976 Jun;57(6):952-9.
Ventilatory responses to carbon dioxide vary widely in patients with bronchial asthma; some have a high response despite increased airway resistance. This paradoxical response was studied in 31 asthmatic children and 22 age-matched healthy children. Measurement of the ventilatory response to carbon dioxide with a conventional rebreathing method showed wide variation in the patients, paralleling the degree of their airway obstruction as measured by the one-second forced expiratory volume and maximal midexpiratory flow rate, but their mean response was similar to that in the control subjects. The ventilatory response was then determined with a new index (Pm100), which rises linearly with increasing carbon dioxide concentration. Despite wide variation in the slope of Pm100 in the patients, their mean response significantly exceeded normal, confirming that the neurochemical drive is increased in bronchial asthma.
支气管哮喘患者对二氧化碳的通气反应差异很大；尽管气道阻力增加，但有些患者仍有高反应性。对31名哮喘儿童和22名年龄匹配的健康儿童进行了这种矛盾反应的研究。用传统的重复呼吸法测量对二氧化碳的通气反应，结果显示患者之间差异很大，这与用一秒用力呼气量和最大呼气中期流速测量的气道阻塞程度平行，但他们的平均反应与对照组相似。然后用一个新指标（Pm100）来测定通气反应，该指标随二氧化碳浓度升高呈线性上升。尽管患者中Pm100斜率差异很大，但他们的平均反应明显超过正常水平，证实支气管哮喘患者的神经化学驱动增强。
