Aldrich J, Ling G V, Ruby A L, Johnson D L, Franti C E
Veterinary Medical Teaching Hospital, University of California, Davis 95616, USA.
J Vet Intern Med. 1997 Sep-Oct;11(5):288-95. doi: 10.1111/j.1939-1676.1997.tb00467.x.
Silica-containing urinary calculi obtained from 773 dogs and submitted by veterinarians throughout the United States were analyzed by quantitative crystallographic analysis to determine mineral composition. Specimens were composed of either multiple mineral layers (535 specimens) or 1 mineral layer (238 specimens). Most multiple-layer calculi were composed of 80% or greater silica (300 of 535, 56%) or 20% to 79% silica (184 of 535, 34%) in any mineral layer. Most 1-layer calculi were composed of 100% silica (212 of 238, 89%). Most dogs forming silica-containing calculi were of male gender (679 of 773, 88%). Bacterial cultures of calculus or urine or both were performed on 49% (376 of 773) of the specimens, and bacterial growth was obtained from 37% (139 of 376) of samples cultured. The prevalence of calculus-associated urinary tract infection was 35% (113 of 321) in males and 47% (26 of 55) in females. The gender prevalence for infection with Staphylococcus species was 16% (51 of 321) in males and 33% (18 of 55) in females. The breed and gender of dogs that formed calculi (silica population) were compared with the hospital population (Veterinary Medical Teaching Hospital [VMTH] population) and with a population of calculus-forming dogs (Stonelab population) to determine risk factors for silica calculus formation. For all breeds compared, the ratio of males to females was higher in the silica population. The German Shepherd Dog and Old English Sheepdog were significantly overrepresented when the silica population was compared with either the VMTH population or the Stonelab population. We conclude that male German Shepherd Dogs and Old English Sheepdogs are at increased risk for formation of silica-containing urinary calculi.
对美国各地兽医提交的773只犬的含硅尿结石进行了定量晶体分析，以确定矿物质成分。标本由多层矿物质（535个标本）或单层矿物质（238个标本）组成。大多数多层结石在任何矿物质层中含硅量为80%或更高（535个中的300个，56%）或20%至79%（535个中的184个，34%）。大多数单层结石由100%的硅组成（238个中的212个，89%）。形成含硅结石的大多数犬为雄性（773只中的679只，88%）。对49%（773个中的376个）的标本进行了结石或尿液或两者的细菌培养，37%（376个培养样本中的139个）的样本有细菌生长。结石相关尿路感染的患病率在雄性中为35%（321个中的113个），在雌性中为47%（55个中的26个）。雄性感染葡萄球菌的性别患病率为16%（321个中的51个），雌性为33%（55个中的18个）。将形成结石的犬（含硅群体）的品种和性别与医院群体（兽医医学教学医院[VMTH]群体）以及结石形成犬群体（结石实验室群体）进行比较，以确定硅结石形成的风险因素。在所有比较的品种中，含硅群体中雄性与雌性的比例更高。当将含硅群体与VMTH群体或结石实验室群体进行比较时，德国牧羊犬和古代英国牧羊犬的比例明显过高。我们得出结论，雄性德国牧羊犬和古代英国牧羊犬形成含硅尿结石的风险增加。
