Ohe O, Arakawa A
Poult Sci. 1976 Mar;55(2):660-5. doi: 10.3382/ps.0550660.
Two experiments were performed to study the effect of dietary antibiotics on percent daily weight change, mortality and gross cecal pathology in chickens during the critical phase of Eimeria tenella infection. In the first experiment, chickens were continuously fed ration containing thiopeptin, 2 mg/kg.; bacitracin, 20 mg./kg.; penicillin, 12 mg./kg.; or chlortetracycline, 22 mg./kg. One day after antibiotic fed was given, each bird received an oral inoculation of 30,000 sporulated oocyts. In the second experiment, chickens were consecutively fed ration containing amprolium plus ethopabate, 125 plus 8 mg./kg., and a combination of the coccidiostat and one of 4 antibiotics; thiopeptin, bacitracin, penicillin, or chloretracycline. One day after medicated feed was given, birds were each given an oral inoculation of 30,000 amprolium plus ethopabate-resistant E. tenella oocysts. The experiments were terminated 7 days after coccidia exposure. In both experiments, E. tenella infection resulted in depression in all birds of infected groups. Average percent weight change of infected birds was significantly lower than that of uninfected unmedicated control between 4 and 5 days after infection. Significantly greater number of birds died of cecal coccidiosis in group fed dietary bacitracin than that of other infected groups. Dietary antibiotics did not reduce gross cecal lesions.
进行了两项实验，以研究日粮抗生素对柔嫩艾美耳球虫感染关键期鸡的日体重变化百分比、死亡率和盲肠大体病理学的影响。在第一项实验中，给鸡持续投喂含硫肽菌素（2毫克/千克）、杆菌肽（20毫克/千克）、青霉素（12毫克/千克）或金霉素（22毫克/千克）的日粮。投喂抗生素一天后，每只鸡口服接种30,000个孢子化卵囊。在第二项实验中，给鸡连续投喂含氨丙啉加乙氧酰胺苯甲酯（125加8毫克/千克）以及一种抗球虫药与4种抗生素之一（硫肽菌素、杆菌肽、青霉素或金霉素）组合的日粮。投喂加药饲料一天后，给每只鸡口服接种30,000个对氨丙啉加乙氧酰胺苯甲酯耐药的柔嫩艾美耳球虫卵囊。球虫暴露7天后终止实验。在两项实验中，柔嫩艾美耳球虫感染导致感染组所有鸡出现精神沉郁。感染鸡的平均体重变化百分比在感染后4至5天显著低于未感染未用药的对照组。饲喂日粮杆菌肽的组中死于盲肠球虫病的鸡数量显著多于其他感染组。日粮抗生素并未减轻盲肠大体病变。
