无症状受试者血清中抗幽门螺杆菌IgG和IgA抗体滴度与胃炎严重程度的关系。
Relation between IgG and IgA antibody titres against Helicobacter pylori in serum and severity of gastritis in asymptomatic subjects.
作者信息
Kreuning J, Lindeman J, Biemond I, Lamers C B
机构信息
Department of Gastroenterology-Hepatology, University Hospital Leiden, The Netherlands.
出版信息
J Clin Pathol. 1994 Mar;47(3):227-31. doi: 10.1136/jcp.47.3.227.
AIMS
To investigate whether the absorbance index of IgG and IgA antibodies against Helicobacter pylori is related to a semiquantitative assessment of the density of H pylori colonisation in gastric biopsy specimens and to the severity of gastritis.
METHODS
The grade of gastritis was scored separately for antral and fundic mucosa using three different classifications. Serum IgA and IgG antibodies against H pylori were measured by ELISA. The density of gastric H pylori colonisation was graded semiquantitatively from 0 to 3.
RESULTS
Among 48 healthy volunteers studied, 17 were found to have gastritis according to Whitehead's criteria. H pylori was present in the biopsy specimens of 14 of 17 subjects with gastritis. The IgG H pylori antibody absorbance index was significantly (p < 0.05) correlated not only with the density of antral H pylori colonisation, but also with the degree of gastritis of the antrum, as assessed by the Whitehead score, activity, and the Sydney system (p < 0.05). The IgA H pylori antibody absorbance index was significantly correlated with the Whitehead score and Sydney system, but not with the activity score of the antrum or with the density of antral gastric H pylori infection. There were no significant correlations between the IgG H pylori antibody absorbance index and the gastritis scores of the fundus mucosa and the density of H pylori infection of the gastric body. The IgA H pylori antibody absorbance index was only significantly (p < 0.05) correlated with the density of H pylori colonisation and the Sydney system gastritis score of the corpus.
CONCLUSIONS
The serological absorbance index of IgG antibodies against H pylori is related to the severity of antral gastritis and the density of antral H pylori colonisation. Thus a high absorbance index of IgG antibodies against H pylori points to severe antral gastritis and dense H pylori colonisation of the antrum.
目的
研究抗幽门螺杆菌IgG和IgA抗体的吸光度指数是否与胃活检标本中幽门螺杆菌定植密度的半定量评估以及胃炎严重程度相关。
方法
采用三种不同分类方法分别对胃窦和胃底黏膜的胃炎分级进行评分。通过酶联免疫吸附测定法检测血清中抗幽门螺杆菌的IgA和IgG抗体。胃幽门螺杆菌定植密度从0到3进行半定量分级。
结果
在研究的48名健康志愿者中，根据怀特黑德标准，发现17人患有胃炎。17名胃炎患者中有14人的活检标本中存在幽门螺杆菌。抗幽门螺杆菌IgG抗体吸光度指数不仅与胃窦幽门螺杆菌定植密度显著相关（p < 0.05），而且与通过怀特黑德评分、活动度和悉尼系统评估的胃窦胃炎程度显著相关（p < 0.05）。抗幽门螺杆菌IgA抗体吸光度指数与怀特黑德评分和悉尼系统显著相关，但与胃窦活动度评分或胃窦幽门螺杆菌感染密度无关。抗幽门螺杆菌IgG抗体吸光度指数与胃底黏膜胃炎评分及胃体幽门螺杆菌感染密度之间无显著相关性。抗幽门螺杆菌IgA抗体吸光度指数仅与胃体幽门螺杆菌定植密度和悉尼系统胃炎评分显著相关（p < 0.05）。
结论
抗幽门螺杆菌IgG抗体的血清学吸光度指数与胃窦胃炎严重程度及胃窦幽门螺杆菌定植密度相关。因此，抗幽门螺杆菌IgG抗体的高吸光度指数表明胃窦胃炎严重且胃窦幽门螺杆菌定植密集。
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