Mirzoeva O K, Grishanin R N, Calder P C
Department of Biochemistry, University of Oxford, United Kingdom.
Microbiol Res. 1997 Sep;152(3):239-46. doi: 10.1016/S0944-5013(97)80034-1.
The effect of the natural bee product propolis on the physiology of microorganisms was investigated using B. subtilis, E. coli and R. sphaeroides. An ethanolic extract of propolis had a bactericidal effect caused by the presence of very active, but labile, ingredients. The exact bactericidal effect of propolis was species dependent: it was effective against gram-positive and some gram-negative bacteria. Propolis and some of its cinnamic and flavonoid components were found to uncouple the energy transducing cytoplasmic membrane and to inhibit bacterial motility. These effects on the bioenergetic status of the membrane may contribute to the antimicrobial action of propolis and its observed synergism with selected antibiotics.
使用枯草芽孢杆菌、大肠杆菌和球形红细菌研究了天然蜂产品蜂胶对微生物生理学的影响。蜂胶乙醇提取物具有杀菌作用，这是由非常活跃但不稳定的成分导致的。蜂胶的确切杀菌作用因菌种而异：它对革兰氏阳性菌和一些革兰氏阴性菌有效。研究发现，蜂胶及其一些肉桂酸和黄酮类成分会使能量转换细胞质膜解偶联，并抑制细菌运动。这些对膜生物能量状态的影响可能有助于蜂胶的抗菌作用及其与某些抗生素的协同作用。
