长期使用卡维地洛治疗可增加慢性充血性心力衰竭患者的副交感神经系统活性。

Long-term carvedilol therapy increases parasympathetic nervous system activity in chronic congestive heart failure.

作者信息

Goldsmith R L, Bigger J T, Bloomfield D M, Krum H, Steinman R C, Sackner-Bernstein J, Packer M

机构信息

Division of Circulatory Physiology, Columbia University, College of Physicians and Surgeons, New York, New York, USA.

出版信息

Am J Cardiol. 1997 Oct 15;80(8):1101-4. doi: 10.1016/s0002-9149(97)00616-4.

DOI:10.1016/s0002-9149(97)00616-4

PMID:9352991

Abstract

To determine the effect of beta blockade on parasympathetic nervous system activity, we assessed RR variability during 24-hour Holter monitoring in 10 patients with congestive heart failure before and after 3 to 4 months of treatment with the beta blocker carvedilol. High-frequency power increased from 26 to 64 ms2, root-mean-square of successive differences in RR interval increased from 14.3 to 23.7 ms2, and percentage of absolute differences >50 ms between successive normal RR intervals increased from 0.8% to 4.7%, all p <0.01, indicating a substantial increase in parasympathetic modulation of RR intervals.

摘要

为确定β受体阻滞剂对副交感神经系统活动的影响，我们在10例充血性心力衰竭患者中，于使用β受体阻滞剂卡维地洛治疗3至4个月前后，通过24小时动态心电图监测评估RR间期变异性。高频功率从26 ms2增加至64 ms2，RR间期连续差值的均方根从14.3 ms2增加至23.7 ms2，连续正常RR间期之间绝对差值>50 ms的百分比从0.8%增加至4.7%，所有p<0.01，表明RR间期的副交感神经调节显著增加。