氯化钠、亚氯酸盐和高氯酸盐对次氯酸盐诱导的磷脂脂质体过氧化的影响。
Effect of sodium chloride, chlorite, and perchlorate on the hypochlorite-induced peroxidation of phospholipid liposomes.
作者信息
Panasenko O M, Arnhold J, Sergienko V I
机构信息
Research Institute of Physico-Chemical Medicine, Russia.
出版信息
Membr Cell Biol. 1997;11(2):253-8.
The abilities of sodium hypochlorite (NaClO), chlorite (NaClO2), chlorate (NaClO3), and perchlorate (NaClO4) to initiate lipid peroxidation (LP) in liposomes formed from unsaturated phosphatidylcholine were compared. It was shown that only NaClO induced an intensive accumulation of LP products (thiobarbituric acid-reactive substances and diene conjugates) in the liposomes as a result of their co-incubation. The other oxochlorates produced no similar effects and did not affect the hypochlorite-induced LP. This indicates that the observed hypochlorite-induced LP does not result from the presence of chlorite, chlorate, or perchlorate anion admixtures in the medium.
比较了次氯酸钠（NaClO）、亚氯酸盐（NaClO₂）、氯酸盐（NaClO₃）和高氯酸盐（NaClO₄）引发由不饱和磷脂酰胆碱形成的脂质体中脂质过氧化（LP）的能力。结果表明，只有NaClO在与脂质体共同孵育时能诱导脂质体中LP产物（硫代巴比妥酸反应性物质和二烯共轭物）的大量积累。其他氯的含氧化合物未产生类似作用，也不影响次氯酸盐诱导的LP。这表明观察到的次氯酸盐诱导的LP并非源于培养基中亚氯酸盐、氯酸盐或高氯酸盐阴离子混合物的存在。
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