Korzun A M, Rozinov S V, Abashin G I
Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch of the Russian Academy of Sciences, Irkutsk.
Membr Cell Biol. 1997;11(2):269-75.
The applicability of the home-made operational amplifier B1404UD1A-1 in a patch-clamp current-to-voltage converter was analyzed. Its parameters (background noise, input bias current, and gain-bandwidth product) were estimated. Schematic solutions and practical recommendations for the use of this amplifier in a current-to-voltage converter were given. Based on the background noise and frequency parameters of the converter, we found that this device can be used for measuring ion channel currents with a high sensitivity and within a broad frequency range (0.055 pA, to 1 kHz; 0.4 pA, to 10 kHz). An example of the converter application in experiments is given.
分析了自制运算放大器B1404UD1A-1在膜片钳电流-电压转换器中的适用性。估计了其参数（背景噪声、输入偏置电流和增益带宽积）。给出了在电流-电压转换器中使用该放大器的原理图解决方案和实际建议。基于转换器的背景噪声和频率参数，我们发现该器件可用于在宽频率范围（0.055 pA至1 kHz；0.4 pA至10 kHz）内高灵敏度地测量离子通道电流。给出了该转换器在实验中的应用示例。
