Mebius R E, Rennert P, Weissman I L
Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands.
Immunity. 1997 Oct;7(4):493-504. doi: 10.1016/s1074-7613(00)80371-4.
For a brief period during fetal lymph node organogenesis in mice, lymph node postcapillary high endothelial venules surprisingly express the Peyer's patch addressin MAdCAM-1. This expression allows initial seeding of this incipient structure by two unusual lymphocyte populations selectively expressing the Peyer's patch homing receptor integrin alpha4beta7: CD4+CD3- oligolineage progenitors and TCR gammadelta+ T cells. We show here that CD4+CD3- cells are lineage-restricted progenitors that express surface lymphotoxin-beta (LTbeta) and the chemokine receptor BLR1 and that can become natural killer cells, dendritic antigen-presenting cells, and follicular cells of unknown outcome, but these cells do not become T or B lymphocytes. Since the necessity of lymphotoxin in lymphoid organ development has been shown, we propose that the novel subset of CD4+CD3-LTbeta+ fetal cells is instrumental in the development of lymphoid tissue architecture.
在小鼠胎儿淋巴结器官发生的短暂时期内，淋巴结毛细血管后高内皮微静脉出人意料地表达派尔集合淋巴结地址素MAdCAM-1。这种表达使得两个选择性表达派尔集合淋巴结归巢受体整合素α4β7的特殊淋巴细胞群体能够最初定植于这个初始结构：CD4⁺CD3⁻寡谱系祖细胞和TCRγδ⁺ T细胞。我们在此表明，CD4⁺CD3⁻细胞是谱系受限的祖细胞，它们表达表面淋巴毒素β（LTβ）和趋化因子受体BLR1，并且能够成为自然杀伤细胞、树突状抗原呈递细胞以及结局未知的滤泡细胞，但这些细胞不会成为T或B淋巴细胞。由于已经证明淋巴毒素在淋巴器官发育中的必要性，我们提出CD4⁺CD3⁻LTβ⁺胎儿细胞的新亚群在淋巴组织结构的发育中起重要作用。
