干扰素-γ介导的对小鼠百日咳博德特氏菌脑内攻击的保护作用。
IFN-gamma-mediated protection against intracerebral challenge with Bordetella pertussis in mice.
作者信息
Sakurai S, Kamachi K, Konda T, Komuro K, Uchida T
机构信息
Department of Bacterial and Blood Products, National Institute of Health, Tokyo.
出版信息
Jpn J Med Sci Biol. 1997 Feb;50(1):35-43.
Mice inoculated with whole cell pertussis vaccine (WCV) acquired protection against intracerebral challenge with Bordetella pertussis without any appreciable antibody production against pertussis toxin or filamentous hemagglutinin. Spleen cells from mice immunized with WCV produced a significant amount of IFN-gamma upon stimulation in vitro with WCV. Furthermore, mice inoculated with recombinant IFN-gamma along with a suboptimal dose of WCV survived longer than those that received WCV alone. These results suggest that, in WCV-immune mice, IFN-gamma plays an important role in protection against intracerebral challenge with B. pertussis.
接种全细胞百日咳疫苗（WCV）的小鼠获得了针对百日咳博德特氏菌脑内攻击的保护，且未产生任何针对百日咳毒素或丝状血凝素的明显抗体。用WCV免疫的小鼠的脾细胞在体外用WCV刺激后产生了大量的γ干扰素。此外，接种重组γ干扰素和次优剂量WCV的小鼠比仅接受WCV的小鼠存活时间更长。这些结果表明，在WCV免疫的小鼠中，γ干扰素在抵抗百日咳博德特氏菌脑内攻击的保护中起重要作用。
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