Bosisio E, Galli C, Galli G, Nicosia S, Spagnuolo C, Tosi L
Prostaglandins. 1976 May;11(5):773-81. doi: 10.1016/0090-6980(76)90186-6.
Levels of free arachidonic acid and of prostaglandin F2alpha and E2 have been measured in both brain cortex and cerebellum of rats killed by focussed microwave irradiation, and after decapitation followed by ischemia. The same parameters were studied during incubation assays. It was found that: a) after ischemia levels of both free arachidonic acid and of prostaglandins in cerebellum are lower than in brain cortex, b) formation of prostaglandins from endogenous precursor in incubated cortex is higher than in cerebellum, c) release of free arachidonic acid occurs mainly during the time interval between the sacrifice of the animals and the beginning of the incubation, whereas prostaglandins are formed mainly during the incubation assay. The correlation between release of free arachidonic acid and prostaglandin formation is discussed.
在通过聚焦微波辐射处死的大鼠以及断头后缺血的大鼠的大脑皮层和小脑中，已对游离花生四烯酸、前列腺素F2α和E2的水平进行了测定。在孵育试验期间也研究了相同的参数。结果发现：a）缺血后，小脑中游离花生四烯酸和前列腺素的水平均低于大脑皮层；b）在孵育的皮层中，由内源性前体形成前列腺素的量高于小脑；c）游离花生四烯酸的释放主要发生在动物处死与孵育开始之间的时间段，而前列腺素主要在孵育试验期间形成。本文讨论了游离花生四烯酸释放与前列腺素形成之间的相关性。
