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Attention and clinical symptoms in schizophrenia.

作者信息

Cornblatt B, Obuchowski M, Schnur D B, O'Brien J D

机构信息

Department of Psychiatry Research, Hillside Hospital, Long Island Jewish Medical Center, Glen Oaks, NY 11004, USA.

出版信息

Psychiatr Q. 1997 Winter;68(4):343-59. doi: 10.1023/a:1025495030997.

DOI:10.1023/a:1025495030997
PMID:9355134
Abstract

Attentional deficits, long established to characterize patients with schizophrenia spectrum disorders, have traditionally been regarded as part of the disorder's clinical syndrome. In this paper we provide evidence to indicate that: a) impaired attention is a dimension of schizophrenia that is independent of clinical state, and b) that attention does not appear to respond to the medication (i.e. standard neuroleptics) most typically used to treat clinical symptoms. Since intact attention and other cognitive processes appear critical to successful functioning in the community after hospital discharge, these findings have major implications for treatment.

摘要

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本文引用的文献

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The effects of neuroleptics on neuropsychological test results of schizophrenics.抗精神病药物对精神分裂症患者神经心理测试结果的影响。
Arch Clin Neuropsychol. 1988;3(3):249-71.
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Attentional functioning in schizotypal personality disorder.分裂型人格障碍中的注意力功能。
Am J Psychiatry. 1997 May;154(5):655-60. doi: 10.1176/ajp.154.5.655.
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Schizophr Bull. 1995;21(4):561-6. doi: 10.1093/schbul/21.4.561.
用于检测与精神分裂症相关认知的NEWMEDS啮齿动物触屏测试组。
Psychopharmacology (Berl). 2015 Nov;232(21-22):3853-72. doi: 10.1007/s00213-015-4007-x. Epub 2015 Jul 24.
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Developing treatments for cognitive deficits in schizophrenia: the challenge of translation.开发精神分裂症认知缺陷的治疗方法:转化的挑战。
J Psychopharmacol. 2015 Feb;29(2):178-96. doi: 10.1177/0269881114555252. Epub 2014 Dec 16.
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Psychosis risk screening in clinical high-risk adolescents: a longitudinal investigation using the Child Behavior Checklist.临床高危青少年的精神病风险筛查:一项使用儿童行为检查表的纵向调查。
Schizophr Res. 2014 Oct;159(1):7-13. doi: 10.1016/j.schres.2014.07.046. Epub 2014 Aug 27.
6
White matter abnormalities and cognitive impairment in early-onset schizophrenia-spectrum disorders.早发性精神分裂症谱系障碍中的白质异常与认知障碍
J Am Acad Child Adolesc Psychiatry. 2014 Mar;53(3):362-72.e1-2. doi: 10.1016/j.jaac.2013.12.007. Epub 2013 Dec 25.
7
Association of a Serotonin Receptor 2A Gene Polymorphism with Visual Sustained Attention in Early-Onset Schizophrenia Patients and their Non-Psychotic Siblings.与早发性精神分裂症患者及其非精神病性兄弟姐妹的视觉持续性注意力相关的 5-羟色胺受体 2A 基因多态性。
Aging Dis. 2012 Aug;3(4):291-300. Epub 2012 Jun 30.
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Multivariate patterns of brain-cognition associations relating to vulnerability and clinical outcome in the at-risk mental states for psychosis.与精神病高危状态下的易感性和临床结局相关的脑-认知关联的多变量模式。
Hum Brain Mapp. 2012 Sep;33(9):2104-24. doi: 10.1002/hbm.21342. Epub 2011 Aug 30.
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Effects of social cognitive impairment on speech disorder in schizophrenia.社会认知障碍对精神分裂症言语障碍的影响。
Schizophr Bull. 2013 May;39(3):608-16. doi: 10.1093/schbul/sbs039. Epub 2012 Mar 13.
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The schizophrenia prodrome: promise for prevention.精神分裂症前驱期:预防的希望
Dialogues Clin Neurosci. 2001 Jun;3(2):93-8. doi: 10.31887/DCNS.2001.3.2/bcornblatt.
4
What are the functional consequences of neurocognitive deficits in schizophrenia?精神分裂症神经认知缺陷的功能后果是什么?
Am J Psychiatry. 1996 Mar;153(3):321-30. doi: 10.1176/ajp.153.3.321.
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Relations between attentional deficits and clinical symptoms in schizophrenic outpatients.精神分裂症门诊患者注意力缺陷与临床症状之间的关系。
Psychiatry Res. 1993 Jun;47(3):205-13. doi: 10.1016/0165-1781(93)90079-v.
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Impaired attention, genetics, and the pathophysiology of schizophrenia.注意力受损、遗传学与精神分裂症的病理生理学
Schizophr Bull. 1994;20(1):31-46. doi: 10.1093/schbul/20.1.31.
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Neuropsychological performance in chronic schizophrenia in response to neuroleptic dose reduction.慢性精神分裂症患者在抗精神病药物剂量减少时的神经心理学表现。
Biol Psychiatry. 1993;33(8-9):575-84. doi: 10.1016/0006-3223(93)90095-u.
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Sustained attention and positive formal thought disorder in schizophrenia.精神分裂症中的持续注意力和阳性形式思维障碍
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Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia.首发精神分裂症未使用过抗精神病药物患者的神经心理学缺陷
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