Nishizaki T, Chew K, Chu L, Isola J, Kallioniemi A, Weidner N, Waldman F M
UCSF Cancer Center, University of California San Francisco, USA.
Int J Cancer. 1997 Oct 21;74(5):513-7. doi: 10.1002/(sici)1097-0215(19971021)74:5<513::aid-ijc6>3.0.co;2-6.
Infiltrating lobular carcinoma (ILC) and infiltrating ductal carcinoma (IDC) are distinguished by their histopathological appearance. However, little is known about the differences in genetic changes between lobular cancers and ductal cancers. We used comparative genomic hybridization (CGH) and compared aberrations in 19 ILCs and 46 IDCs. The total number of aberrations was lower in ILC than in IDC. While the average number of DNA copy number losses did not reach significance between them, copy number gains were significantly lower in ILCs. Fifteen of 19 ILCs (79%) showed increased copy number of 1q, and 12 cases (63%) revealed loss of 16q. The presence of these aberrations was independent of nodal status, histologic subtypes (pleomorphic or classic ILC), or BrdUrd-labeling index. ILCs had a higher frequency of 16q loss than did ductal cancers, and a lower frequency of 8q and 20q gains. Our data suggest that the altered growth pattern and clinical presentation which characterize infiltrating lobular cancers are correlated with distinct genetic alterations.
浸润性小叶癌（ILC）和浸润性导管癌（IDC）可通过组织病理学表现加以区分。然而，关于小叶癌和导管癌之间基因变化的差异却知之甚少。我们采用比较基因组杂交（CGH）技术，对19例ILC和46例IDC的畸变情况进行了比较。ILC的畸变总数低于IDC。虽然它们之间DNA拷贝数丢失的平均数未达到显著差异，但ILC中拷贝数增加明显更低。19例ILC中有15例（79%）显示1q拷贝数增加，12例（63%）显示16q缺失。这些畸变的存在与淋巴结状态、组织学亚型（多形性或经典型ILC）或BrdUrd标记指数无关。ILC中16q缺失的频率高于导管癌，而8q和20q增加的频率低于导管癌。我们的数据表明，浸润性小叶癌所特有的生长模式改变和临床表现与独特的基因改变相关。
