Ball S, Shekhar A
Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202-5266, USA.
Am J Psychiatry. 1997 Nov;154(11):1603-4. doi: 10.1176/ajp.154.11.1603.
The purpose of this study was to measure the response of basilar artery blood flow to hyperventilation in patients with panic disorder.
Transcranial Doppler ultrasonography was used to measure basilar artery flow during rest and after hyperventilation in 16 patients with panic disorder and eight normal comparison subjects. The subjects rated their dizziness at each phase.
The patients with panic disorder demonstrated greater reduction in flow rates and greater increases in dizziness than the normal comparison subjects.
The greater basilar artery sensitivity to hyperventilation shown by panic disorder patients suggests a possible mechanism for the development of neurological symptoms during panic attacks.
本研究旨在测量惊恐障碍患者基底动脉血流对过度换气的反应。
采用经颅多普勒超声检查，对16例惊恐障碍患者和8名正常对照者在静息状态和过度换气后测量基底动脉血流。受试者在每个阶段对自己的头晕程度进行评分。
与正常对照者相比，惊恐障碍患者的血流速度降低幅度更大，头晕程度增加更明显。
惊恐障碍患者对过度换气表现出更高的基底动脉敏感性，这提示了惊恐发作期间神经症状发生的一种可能机制。
