Schunck C, Obe G
Department of Genetics, University of Essen, Germany.
Mutat Res. 1997 Oct 6;379(2):233-9. doi: 10.1016/s0027-5107(97)00154-1.
In this paper we show that sister chromatid exchanges (SCE) can be analysed by computer-supported determination of areas and shapes of darkly stained chromatid sections. In combination with appropriate statistical analyses, our method leads to measurements of SCE frequencies in neocarzinostatin-treated Chinese hamster ovary cells which are nearly as precise as the ones obtained by classical microscopical analyses. We discuss our data as an approach to the development of a fully automated SCE scoring system.
