Fukushima M, Matsuda T, Yamagishi K, Nakano M
Department of Bioresource Chemistry, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
Lipids. 1997 Oct;32(10):1069-74. doi: 10.1007/s11745-997-0138-5.
Rats (8 wk of age) fed a conventional diet were shifted to diets containing 10% Oenothera biennis Linn oil (OBLO, linoleic acid + gamma-linolenic acid) from a wild plant, evening primrose oil (EPO, linoleic acid + gamma-linolenic acid) from a cultivated plant, bio-gamma-linolenic acid oil from mold (BIO, palmitic acid + oleic acid + linoleic acid + gamma-linolenic acid), safflower oil (linoleic acid), palm oil (PLO, palmitic acid + oleic acid + linoleic acid), or soybean oil (linoleic acid + alpha-linolenic acid) with 0.5% cholesterol for 13 wk. Though there were no significant differences in the food intake among the groups, the body weight gain of the OBLO group was significantly lower than that of the other groups except for the BIO and PLO groups, and that of the EPO and SBO groups were the highest among the groups. The liver weight of the OBLO group was significantly lower than that of other groups, and that of the PLO group was the highest among the groups. The serum total cholesterol and very low density lipoprotein (VLDL) + intermediate density lipoprotein (IDL) + low density lipoprotein (LDL) cholesterol concentrations of the OBLO and EPO groups were consistently lower than those in the other groups. However, those of the BIO group were higher than those in the OBLO and EPO groups. The liver cholesterol concentration of the PLO group was the highest among all groups except for the EPO group. The fecal neutral sterol and bile acid extraction of the BIO group tended to increase compared to the other groups. The results of this study demonstrate that OBLO and EPO inhibit the increasing of serum total cholesterol and VLDL + IDL + LDL-cholesterol concentrations in the presence of excess cholesterol in the diet compared with the other dietary oils.
将8周龄的大鼠由常规饮食改为含10%月见草油（OBLO，来自野生植物，含亚油酸+γ-亚麻酸）、月见草油（EPO，来自栽培植物，含亚油酸+γ-亚麻酸）、霉菌来源的生物γ-亚麻酸油（BIO，含棕榈酸+油酸+亚油酸+γ-亚麻酸）、红花油（亚油酸）、棕榈油（PLO，含棕榈酸+油酸+亚油酸）或大豆油（含亚油酸+α-亚麻酸）并添加0.5%胆固醇的饮食，持续13周。尽管各组之间食物摄入量无显著差异，但OBLO组的体重增加显著低于除BIO和PLO组之外的其他组，而EPO组和SBO组的体重增加在各组中最高。OBLO组的肝脏重量显著低于其他组，PLO组的肝脏重量在各组中最高。OBLO组和EPO组的血清总胆固醇以及极低密度脂蛋白（VLDL）+中间密度脂蛋白（IDL）+低密度脂蛋白（LDL）胆固醇浓度始终低于其他组。然而，BIO组的这些指标高于OBLO组和EPO组。除EPO组外，PLO组的肝脏胆固醇浓度在所有组中最高。与其他组相比，BIO组的粪便中性固醇和胆汁酸提取量有增加趋势。本研究结果表明，与其他食用油相比，在饮食中存在过量胆固醇的情况下，OBLO和EPO可抑制血清总胆固醇以及VLDL+IDL+LDL胆固醇浓度的升高。
