（+）-α-（N-1-苯乙基）脲立体特异性抑制钙离子刺激的线粒体呼吸，但不抑制二磷酸腺苷刺激的线粒体呼吸。
(+)-alpha-(N-1-phenethyl) urea stereospecifically inhibits Ca2+ - but not ADP-stimulated mitochondrial respiration.
作者信息
Davidoff F, Haas D, Bertolini D
出版信息
Science. 1976 Jul 2;193(4247):66-8. doi: 10.1126/science.935857.
PMID:935857
Abstract
The (+) isomer of alpha-(N-1-phenethyl) urea is a moderately potent inhibitor of Ca2+ -stimulated mitochondrial respiration of 45Ca2+ uptake (50 percent inhibition at 0.18 mM) while having no effect on adenosine diphosphate-stimulated respiration; the (-) isomer is without effect up to 4 mM. beta-Phenethylurea does not inhibit with either stimulus. The data support the involvement of a Ca2+ -specific protein in energized mitochondrial Ca2+ uptake.
摘要
α-（N-1-苯乙基）脲的（+）异构体是Ca2+刺激的线粒体呼吸和45Ca2+摄取的中度有效抑制剂（在0.18 mM时50%抑制），而对二磷酸腺苷刺激的呼吸无影响；（-）异构体在高达4 mM时无作用。β-苯乙基脲对两种刺激均无抑制作用。这些数据支持一种Ca2+特异性蛋白参与了活跃的线粒体Ca2+摄取。
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