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Hepatocytes break the rules of senescence in serial transplantation studies. Is there a limit to their replicative capacity?在连续移植研究中，肝细胞打破了衰老规律。它们的复制能力有极限吗？
Am J Pathol. 1997 Nov;151(5):1187-9.
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Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes.连续移植揭示了成年小鼠肝细胞的干细胞样再生潜力。
Am J Pathol. 1997 Nov;151(5):1273-80.

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Multi-omics analysis reveals distinct gene regulatory mechanisms between primary and organoid-derived human hepatocytes.多组学分析揭示了原代和类器官来源的人肝细胞之间不同的基因调控机制。
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Front Cell Dev Biol. 2020 Oct 14;8:564581. doi: 10.3389/fcell.2020.564581. eCollection 2020.
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Animal models for the study of HCV.用于丙型肝炎病毒研究的动物模型。
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A model of liver regeneration.肝脏再生模型。
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Expression of stromal cell-derived factor-1 and of its receptor CXCR4 in liver regeneration from oval cells in rat.基质细胞衍生因子-1及其受体CXCR4在大鼠卵圆细胞肝再生中的表达
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Hepatocyte transplantation into diseased mouse liver. Kinetics of parenchymal repopulation and identification of the proliferative capacity of tetraploid and octaploid hepatocytes.将肝细胞移植到患病小鼠肝脏中。实质细胞再填充的动力学以及四倍体和八倍体肝细胞增殖能力的鉴定。
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Long-term expression of human coagulation factor VIII and correction of hemophilia A after in vivo retroviral gene transfer in factor VIII-deficient mice.人凝血因子VIII在VIII因子缺陷小鼠体内经逆转录病毒基因转移后的长期表达及甲型血友病的纠正
Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10379-84. doi: 10.1073/pnas.96.18.10379.

本文引用的文献

1
Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes.连续移植揭示了成年小鼠肝细胞的干细胞样再生潜力。
Am J Pathol. 1997 Nov;151(5):1273-80.
2
Liver regeneration.肝脏再生
Science. 1997 Apr 4;276(5309):60-6. doi: 10.1126/science.276.5309.60.
3
Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor.肿瘤坏死因子引发肝脏生长：缺乏I型肿瘤坏死因子受体的小鼠肝脏再生缺陷。
Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1441-6. doi: 10.1073/pnas.94.4.1441.
4
Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.白细胞介素-6缺陷小鼠的肝衰竭与肝细胞再生缺陷
Science. 1996 Nov 22;274(5291):1379-83. doi: 10.1126/science.274.5291.1379.
5
Liver regeneration 3: Regulation of signal transduction during liver regeneration.肝脏再生3：肝脏再生过程中信号转导的调控
FASEB J. 1996 Feb;10(2):215-27. doi: 10.1096/fasebj.10.2.8641555.
6
Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I.在I型遗传性酪氨酸血症小鼠模型中，通过基因疗法校正的肝细胞在体内被筛选出来。
Nat Genet. 1996 Mar;12(3):266-73. doi: 10.1038/ng0396-266.
7
Replacement of diseased mouse liver by hepatic cell transplantation.通过肝细胞移植替换患病小鼠的肝脏。
Science. 1994 Feb 25;263(5150):1149-52. doi: 10.1126/science.8108734.
8
Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha.源自转化生长因子α转基因小鼠的分化、未转化肝细胞系的建立与特性研究
Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):674-8. doi: 10.1073/pnas.91.2.674.
9
Complete reconstitution of mouse liver with xenogeneic hepatocytes.用异种肝细胞完全重建小鼠肝脏。
Proc Natl Acad Sci U S A. 1995 May 23;92(11):4942-6. doi: 10.1073/pnas.92.11.4942.
10
Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I.遗传性I型酪氨酸血症小鼠模型中新生儿致死性肝功能障碍的药理学纠正
Nat Genet. 1995 Aug;10(4):453-60. doi: 10.1038/ng0895-453.

Hepatocytes break the rules of senescence in serial transplantation studies. Is there a limit to their replicative capacity?

作者信息

Fausto N

机构信息

Department of Pathology, University of Washington, Seattle 98195-7705, USA.

出版信息

Am J Pathol. 1997 Nov;151(5):1187-9.

PMID:9358742
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1858101/
Abstract
摘要