Grogan J L, Kremsner P G, van Dam G J, Deelder A M, Yazdanbakhsh M
Department of Parasitology, Leiden University, Netherlands.
J Infect Dis. 1997 Nov;176(5):1344-50. doi: 10.1086/514131.
Specific IgG4 and IgE responses to adult worm antigen (AWA) and soluble egg antigen (SEA) were examined in 37 subjects from an area in which schistosomiasis is endemic, who were previously infected with Schistosoma haematobium and who became reinfected or remained free of infection 2 years after chemotherapy. The reinfected group was significantly younger (median age, 11 years) than the uninfected group (median age, 24 years). Posttreatment levels of IgG4 to egg antigens (IgG4-SEA) were significantly correlated with reinfection intensity (r = .74, P < .0001), and 13-fold lower levels of IgG4-SEA were observed in uninfected subjects compared with reinfected subjects. Although no correlation was observed between posttreatment IgE to AWA or to SEA, pretreatment IgE-AWA was inversely correlated with the level of reinfection (r = -.39, P = .02).
在血吸虫病流行地区的37名受试者中检测了针对成虫抗原（AWA）和可溶性虫卵抗原（SEA）的特异性IgG4和IgE反应，这些受试者先前感染过埃及血吸虫，化疗后2年再次感染或未感染。再次感染组明显比未感染组年轻（中位年龄11岁 vs 24岁）。治疗后针对虫卵抗原的IgG4水平（IgG4-SEA）与再次感染强度显著相关（r = 0.74，P < 0.0001），未感染受试者的IgG4-SEA水平比再次感染受试者低13倍。尽管治疗后针对AWA或SEA的IgE之间未观察到相关性，但治疗前IgE-AWA与再次感染水平呈负相关（r = -0.39，P = 0.02）。
