Elves M W
Transplantation. 1976 Jul;22(1):31-6. doi: 10.1097/00007890-197607000-00005.
The effect of two doses of X-irradiation upon the osteogenesis in isografts or allografts of cancellous bone has been studied. Exposure of rats to 500 rads of X-irradiation caused a transient depression in osteogenesis in the skeleton. This depression was more marked, however, after 600 rads of X-ray. Five hundred rads of X-ray had no effect upon the level of osteogenesis in isografts 2 weeks after grafting, but did depress new bone formation in 3-week-old grafts. The higher dose of X-rays caused a more profound depression in new bone formation at both 2 and 3 weeks. Both 500 rads and 600 rads of X-ray had little effect upon the degree of first phase osteogenesis in H-1 disparate allografts. However, there was some improvement in late phase new bone formation in recipients treated with 600 rads. Both doses of X-rays markedly improved the amount of first phase osteogenesis in H-1 identical allografts. There was also a significant improvement in the new bone formation in grafts in the second phase. The significance of these findings is discussed.
研究了两剂量X射线照射对松质骨同基因移植或异基因移植中骨生成的影响。将大鼠暴露于500拉德的X射线照射下会导致骨骼中骨生成出现短暂抑制。然而，在600拉德的X射线照射后，这种抑制更为明显。500拉德的X射线对移植后2周的同基因移植中的骨生成水平没有影响，但确实会抑制3周龄移植中的新骨形成。更高剂量的X射线在2周和3周时都会导致新骨形成更严重的抑制。500拉德和600拉德的X射线对H-1不相合异基因移植中第一阶段骨生成的程度影响很小。然而，接受600拉德治疗的受体在后期新骨形成方面有一些改善。两剂量的X射线均显著改善了H-1相同异基因移植中第一阶段骨生成的量。移植在第二阶段的新骨形成也有显著改善。讨论了这些发现的意义。
