Wallis N T, Banerjee S S, Eyden B P, Armstrong G R
Department of Histopathology, Christie Hospital NHS Trust, Manchester, UK.
Histopathology. 1997 Oct;31(4):374-7. doi: 10.1046/j.1365-2559.1997.2700863.x.
The histological, immunohistochemical and electron microscopic features of a primary adenomyoepithelioma of skin, a rare sweat gland tumour, are reported.
The tumour occurred on the back of a 92-year-old woman. It was composed of well-formed tubules lined by epithelial cells surrounded by clear or spindled myoepithelial cells. Immunohistochemically, the epithelial cells exhibited strong cytokeratin (CAM5.2) and weak carcinoembryonic antigen positivity. The myoepithelial cells showed diffuse positivity for smooth muscle actin and focal positivity for S100 protein. Ultrastructurally, the myoepithelial cells contained myofilaments with focal densities and hemidesmosomes. They were limited by well-formed basal lamina. The tumour was associated with a small eccrine spiradenoma.
We predict that the tumour will behave in a benign fashion. There is no evidence of recurrence or metastasis 28 months later.
报告一种罕见的汗腺肿瘤——原发性皮肤腺肌上皮瘤的组织学、免疫组化及电子显微镜特征。
肿瘤发生于一名92岁女性的背部。它由结构良好的小管组成，内衬上皮细胞，周围是透明或梭形的肌上皮细胞。免疫组化显示，上皮细胞呈现强细胞角蛋白（CAM5.2）阳性及弱癌胚抗原阳性。肌上皮细胞平滑肌肌动蛋白弥漫阳性，S100蛋白局灶阳性。超微结构上，肌上皮细胞含有具有局灶性致密物和半桥粒的肌丝。它们被结构良好的基膜所限制。该肿瘤与一个小的外分泌螺旋腺瘤相关。
我们预计该肿瘤将表现为良性。28个月后无复发或转移迹象。
