抗氧化维生素对二氧化硫吸入诱导的红细胞脂质过氧化的保护作用。
Protective effect of antioxidant vitamins on red blood cell lipoperoxidation induced by SO2 inhalation.
作者信息
Etlik O, Tomur A, Tuncer M, Ridvanağaoğlu A Y, Andaç O
机构信息
Department of Physiology, Faculty of Medicine, Gülhane Military Medical Academy, Ankara, Turkey.
出版信息
J Basic Clin Physiol Pharmacol. 1997;8(1-2):31-43. doi: 10.1515/jbcpp.1997.8.1-2.31.
The aim of this research was to determine whether administration of antioxidant vitamins can reduce oxidant damage in erythrocytes induced by sulfur dioxide (SO2) inhalation. Meth- and sulfhemoglobin ratios, malonyldialdehyde (MDA) levels, osmotic fragility ratios and hematological parameters of a total of 28 rats were compared. SO2 was given at 10 ppm, 1 hour daily, for 45 days in a specially designed chamber. DL-alpha-Tocopherol acetate (40 mg/kg) and Na-ascorbate (200 mg/kg) treatments, initiated 3 days before SO2 exposures, were applied intraperitoneally 3 times a week for 45 days. Meth- and sulfhemoglobin ratios, MDA levels and osmotic fragility ratios were significantly higher in the SO2-treated group (p < 0.05). Significant decreases in MDA levels and osmotic fragility ratios were observed in the antioxidant-treated group (p < 0.05). SO2 inhalation resulted in higher MDA levels and osmotic fragility ratios, which can be reduced by vitamin E + C combination.
本研究的目的是确定给予抗氧化剂维生素是否能减少吸入二氧化硫（SO₂）诱导的红细胞氧化损伤。比较了总共28只大鼠的高铁血红蛋白和硫化血红蛋白比率、丙二醛（MDA）水平、渗透脆性比率和血液学参数。在一个特别设计的舱室内，以10 ppm的浓度每天给予SO₂ 1小时，持续45天。在SO₂暴露前3天开始，每周腹腔注射3次DL-α-生育酚醋酸酯（40 mg/kg）和抗坏血酸钠（200 mg/kg），持续45天。SO₂处理组的高铁血红蛋白和硫化血红蛋白比率、MDA水平和渗透脆性比率显著更高（p < 0.05）。抗氧化剂处理组的MDA水平和渗透脆性比率显著降低（p < 0.05）。吸入SO₂导致MDA水平和渗透脆性比率升高，而维生素E + C联合使用可降低这些指标。
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