van der Gaag I, Happé R P, Wolvekamp W T
Vet Pathol. 1976;13(3):172-85. doi: 10.1177/030098587601300302.
Chronic hypertrophic gastritis in a 7-year-old Boxer dog is described. This gastritis resembles Menetrier's disease in man. The dog was emaciated, lethargic, vomiting and had a poor appetite over a 4-month period. There was anaemia, and the blood smear was characterized by hypochromasia, strong anisoplania and striking poikilocytosis. There was a protein loss and at a later stage of the disease, a hypoalbuminaemia. On gastroscopic examination the plicae gastricae were numerous and strongly marked; moreover, they were granulated with numerous small haemorrhages. Radiographically, the stomach had a marked folding, primarily at the greater curvature. The passage of contrast medium from the stomach into the duodenum was strongly retarded. The pathological findings included macroscopical folding caused by local gland cell hyperplasia in the body as well as the pylorus, foveolar hyperplasia and, in the fundus and in the corpus near the greater curvature, folding of the muscularis mucosae and the submucosa. A superficial gastritis was found particularly in the fundus and corpus, whereas the pyloric antrum showed a more diffuse inflammation.
描述了一只7岁拳师犬的慢性肥厚性胃炎。这种胃炎类似于人类的梅内特里耶病。这只狗在4个月的时间里消瘦、嗜睡、呕吐且食欲不振。存在贫血，血液涂片的特征为低色素性、明显的红细胞大小不均和显著的异形红细胞症。有蛋白质丢失，在疾病后期出现低白蛋白血症。胃镜检查显示胃皱襞众多且明显；此外，它们呈颗粒状，有许多小出血点。放射学检查显示胃有明显的褶皱，主要在大弯处。造影剂从胃进入十二指肠的过程严重受阻。病理检查结果包括胃体以及幽门局部腺细胞增生导致的宏观褶皱、小凹增生，在胃底和大弯附近的胃体部，黏膜肌层和黏膜下层出现褶皱。特别是在胃底和胃体部发现了浅表性胃炎，而幽门窦则显示出更弥漫性的炎症。
