Petersen E E, Neumann-Haefelin D, Kärnbach M, Haas R
Dtsch Med Wochenschr. 1977 Jul 1;102(26):954-8. doi: 10.1055/s-0028-1104995.
The rubella antibody titres were evaluated in 158 girls who had been seronegative prior to immunization and had been immunised 4 years previously (1971) with the rubella vaccine HPV77DE5. In 138 girls (87%) the 1975 titres were unchanged in comparison with 1971. Only in 5 girls (3.2%) the titres had decreased by up to 2 log2 steps. In two patients the titre reached the critical value of 1:8 which must be considered negative due to the high sensitivity of the haemagglutination inhibition test. A titre increase by two or more steps was observed in 15 girls (9.5%). A third of the titre increases might be due to reinfection with rubella wild virus which would correspond to a reinfection rate of less than 1% per year. Present knowledge indicates that reinfection during pregnancy does not endanger the unborn child.
对158名女孩的风疹抗体滴度进行了评估，这些女孩在免疫前血清学呈阴性，于4年前（1971年）接种了风疹疫苗HPV77DE5。138名女孩（87%）1975年的滴度与1971年相比没有变化。只有5名女孩（3.2%）的滴度下降了多达2个log2级别。两名患者的滴度达到了1:8的临界值，由于血凝抑制试验的高灵敏度，该值必须被视为阴性。15名女孩（9.5%）的滴度升高了两个或更多级别。三分之一的滴度升高可能是由于风疹野生病毒的再次感染，这相当于每年的再感染率低于1%。目前的知识表明，孕期再次感染不会危及未出生的胎儿。
