Ino-oka N, Inoue A, Shindoh Y, Suzuki T, Konishi K
Sendai City Medical Center, Sendai Open Hospital, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Aug;35(8):867-72.
A 44-year-old Japanese man who had suffered from bronchial asthma since childhood was given the diagnosis of chronic eosinophilic pneumonia because of his symptoms, chest roentgenographic findings, and the results of a transbronchial lung biopsy. At the time of the onset of the disease, the pleural effusion contained 73% eosinophils. Symptoms were relieved and the laboratory findings returned forward normal after a short course of high-dose corticosteroids. The concentrations of IL-5, IL-6, and G-CSF in pleural fluid and in serum were very high; the concentrations of these cytokines were 3 times to 35 times higher in pleural fluid than in serum. In contrast, no IL-3 or GM-CSF was detected in any of these samples. The precise etiology of chronic eosinophilic pneumonia is still unclear, but this case suggests that inappropriate production of IL-5, IL-6 and G-CSF in the lung play a pivotal role in this disease. Inhibition of the production of these cytokines may be another therapeutic approach to this disease.
一名自幼患有支气管哮喘的44岁日本男性，因其症状、胸部X线检查结果及经支气管肺活检结果，被诊断为慢性嗜酸性粒细胞性肺炎。疾病发作时，胸腔积液中嗜酸性粒细胞占73%。经过短期大剂量皮质类固醇治疗后，症状缓解，实验室检查结果恢复正常。胸腔积液和血清中IL-5、IL-6和G-CSF的浓度非常高；这些细胞因子在胸腔积液中的浓度比血清中高3倍至35倍。相比之下，在这些样本中均未检测到IL-3或GM-CSF。慢性嗜酸性粒细胞性肺炎的确切病因仍不清楚，但该病例表明，肺部IL-5、IL-6和G-CSF的异常产生在该疾病中起关键作用。抑制这些细胞因子的产生可能是治疗该疾病的另一种方法。
