Yang F Y, Li S Z, Liu Y Z
Department of Ophthalmology, Nanfang Hospital, First Military Medical University, Guangzhou, P.R. China.
J Cataract Refract Surg. 1997 Oct;23(8):1265-70. doi: 10.1016/s0886-3350(97)80326-4.
To study the pathogenesis of membrane formation and cellular response on the surface of posterior chamber intraocular lenses (IOLs) implanted in rabbits.
Department of Histology and Embryology, Pathology, Ophthalmology. The First Military Medical University, Guangzhou, P.R. China.
Thirty rabbits had extracapsular lens extraction and posterior chamber IOL implantation. The IOLs were removed 4, 7, 15, 30, and 90 days postoperatively. Membrane formation and cellular response on IOL surfaces were evaluated using light (n = 25), transmission (n = 5), and scanning electron (n = 5) microscopy.
On 30 IOLs, the incidence of cellular adhesion was 100%. Cellular components comprised macrophages, fibroblast-like cells, epithelioid cells, giant cells, ultralarge giant cells, and lymphocytes. A thin, proteinaceous film was also seen on the surface of the IOLs. The membrane of the IOL surface comprised fibrin, collagen fibrils, macrophages, fibroblast-like cells, giant cells, and fibroblasts.
The findings of this study might apply to humans because cellular elements and membranes have been reported in humans.
研究兔眼植入后房型人工晶状体（IOL）表面膜形成及细胞反应的发病机制。
中国广州第一军医大学组织学与胚胎学系、病理学系、眼科。
30只兔行晶状体囊外摘除及后房型IOL植入术。术后4、7、15、30和90天取出IOL。使用光学显微镜（n = 25）、透射电子显微镜（n = 5）和扫描电子显微镜（n = 5）评估IOL表面的膜形成及细胞反应。
在30个IOL上，细胞黏附的发生率为100%。细胞成分包括巨噬细胞、成纤维细胞样细胞、上皮样细胞、巨细胞、超大巨细胞和淋巴细胞。在IOL表面还可见一层薄的蛋白质膜。IOL表面的膜由纤维蛋白、胶原纤维、巨噬细胞、成纤维细胞样细胞、巨细胞和成纤维细胞组成。
本研究结果可能适用于人类，因为在人类中也有细胞成分和膜的报道。
