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不同来源金黄色葡萄球菌菌株产肠毒素的研究(作者译)

[Studies of enterotoxin production by strains of Staphylococcus aureus of different origins (author's transl)].

作者信息

Mochmann H, Richter U, Karsch W, Witte W, Meyer W

出版信息

Zentralbl Bakteriol Orig A. 1976 May;234(4):434-49.

PMID:936826
Abstract

376 Staphylococcus aureus strains of clinical and epidemiological origin were tested for their ability to produce the enterotoxins, A, B and C1. For these investigations, microagargel precipitation against specific antisera has been used. Additionally these strains were studied by phagetyping, biochemical typing and for their antibiogram. The strains tested came from human pathological processes, mouth throat swabs of healthy people, persons working in hospitals, outbreaks of food poisoning from cows suffering from mastritis and some from milk samples. Most of the strains isolated from food poisonings were associated with enterotoxin-A-production. Among the group of strains from autopsy material, the enterotoxin-B-producing strains were predominant. The strains from human pathological processes which were found to be enterotoxin producing, were mostly belonging to phage group III. With regard to the antibiogram, the enterotoxin-producing strains were somewhat more resistent than the enterotoxin-negative strains. Correlations between the production of enterotoxin B and methicillin resistance did not become evident in our material. The strains were differentiated, too, as to their classification as var. hominis or var. bovis. With one exception, all enterotoxin-producing strains which could be classified in this way, were belonging to var. hominis. From five enterotoxin-producing strains isolated from cattle, only one strain belonged to var. bovis, the other to var. hominis. Obviously the ability to produce the enterotoxins, A, B and C1 is very rare in the group of var. bovis strains.

摘要

对376株具有临床和流行病学来源的金黄色葡萄球菌菌株进行了产生A、B和C1型肠毒素能力的检测。对于这些研究,采用了针对特异性抗血清的微量琼脂凝胶沉淀法。此外,还通过噬菌体分型、生化分型及其抗菌谱对这些菌株进行了研究。所检测的菌株来自人类病理过程、健康人的口咽拭子、医院工作人员、患乳腺炎奶牛的食物中毒暴发以及一些牛奶样本。从食物中毒中分离出的大多数菌株与产生肠毒素A有关。在尸检材料的菌株组中,产生肠毒素B的菌株占主导地位。从人类病理过程中发现的产肠毒素菌株大多属于噬菌体III组。关于抗菌谱,产肠毒素菌株比不产肠毒素菌株的耐药性略强。在我们的材料中,肠毒素B的产生与耐甲氧西林之间的相关性并不明显。这些菌株在分类上也被区分为人型变种或牛型变种。除一例例外,所有可如此分类的产肠毒素菌株均属于人型变种。从牛分离出的5株产肠毒素菌株中,只有1株属于牛型变种,其他属于人型变种。显然,在牛型变种菌株组中产生A、B和C1型肠毒素的能力非常罕见。

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