Sakai T, Okamoto S, Iwaki Y
Second Department of Ophthalmology, Toho University School of Medicine, Tokyo, Japan.
Nippon Ganka Gakkai Zasshi. 1997 Oct;101(10):783-7.
Recent studies have reported that tranilast inhibited in vitro the proliferation of keratocytes from corneal subepithelial opacities (haze) and collagen synthesis in cultured corneas after excimer laser photorefractive keratectomy (PRK). In this study 0.5% tranilast eye drops, 0.1% betametazone phosphate eyedrops, and a 0.5% tranilast base solution (control) were administered four times daily to rabbits which had undergone PRK. Weekly evaluation of the inhibitory effect of these drugs on haze began two weeks after surgery according to Fantes' classification. 0.5% tranilast suppressed haze from six weeks to thirteen weeks after PRK (p < 0.05). 0.1% betametazone phosphate showed no effect. These results suggested that 0.5% tranilast had a satisfactory therapeutic effect on haze after PRK.
最近的研究报告称，曲尼司特在体外可抑制角膜基质层混浊（ haze ）中角膜细胞的增殖以及准分子激光屈光性角膜切削术（ PRK ）后培养角膜中的胶原合成。在本研究中，对接受 PRK 的兔每日 4 次给予 0.5% 曲尼司特滴眼液、 0.1% 磷酸倍他米松滴眼液和 0.5% 曲尼司特基础溶液（对照）。根据 Fantes 分级，术后两周开始每周评估这些药物对 haze 的抑制作用。 0.5% 曲尼司特在 PRK 后 6 周～ 13 周抑制了 haze （ p<0.05 ）。 0.1% 磷酸倍他米松无作用。这些结果表明， 0.5% 曲尼司特对 PRK 后的 haze 有满意的治疗效果。
