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Modulation of apoptosis by adenosine in the central nervous system: a possible role for the A3 receptor. Pathophysiological significance and therapeutic implications for neurodegenerative disorders.

作者信息

Abbracchio M P, Ceruti S, Brambilla R, Franceschi C, Malorni W, Jacobson K A, von Lubitz D K, Cattabeni F

机构信息

Institute of Pharmacological Sciences, Milan, Italy.

出版信息

Ann N Y Acad Sci. 1997 Oct 15;825:11-22. doi: 10.1111/j.1749-6632.1997.tb48410.x.

DOI:10.1111/j.1749-6632.1997.tb48410.x
PMID:9369971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3457635/
Abstract
摘要

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Modulation of apoptosis by adenosine in the central nervous system: a possible role for the A3 receptor. Pathophysiological significance and therapeutic implications for neurodegenerative disorders.腺苷对中枢神经系统细胞凋亡的调节作用：A3受体的潜在作用。对神经退行性疾病的病理生理意义及治疗启示。
Ann N Y Acad Sci. 1997 Oct 15;825:11-22. doi: 10.1111/j.1749-6632.1997.tb48410.x.
2
Brain adenosine receptors as targets for therapeutic intervention in neurodegenerative diseases.脑腺苷受体作为神经退行性疾病治疗干预的靶点。
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3
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Adenosine A2A receptors and neuroprotection.腺苷A2A受体与神经保护作用
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本文引用的文献

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Species Differences in Ligand Affinity at Central A-Adenosine Receptors.中枢A1-腺苷受体配体亲和力的种属差异。
Drug Dev Res. 1994 Sep;33(1):51-59. doi: 10.1002/ddr.430330109.
2
A-adenosine receptors: design of selective ligands and therapeutic prospects.A 型腺苷受体：选择性配体的设计与治疗前景
Drugs Future. 1995 Jul;20(7):689-699. doi: 10.1358/dof.1995.020.07.531583.
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Molecular Architecture of G Protein-Coupled Receptors.G蛋白偶联受体的分子结构
Drug Dev Res. 1996 Jan 1;37(1):1-38. doi: 10.1002/(SICI)1098-2299(199601)37:1<1::AID-DDR1>3.0.CO;2-S.
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Bcl-2 relieves deoxyadenylate stress and suppresses apoptosis in pre-B leukemia cells.Bcl-2 减轻脱氧腺嘌呤核苷的压力并抑制前 B 白血病细胞的凋亡。
Cell Death Differ. 1995 Jan;2(1):69-78.
5
Apoptotic features of selective neuronal death in ischemia, epilepsy and gp 120 toxicity.缺血、癫痫和gp 120毒性中选择性神经元死亡的凋亡特征。
Trends Neurosci. 1996 Mar;19(3):109-14. doi: 10.1016/s0166-2236(96)80039-7.
6
G protein-dependent activation of phospholipase C by adenosine A3 receptors in rat brain.大鼠脑中腺苷A3受体通过G蛋白依赖性激活磷脂酶C
Mol Pharmacol. 1995 Dec;48(6):1038-45.
7
Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells.细胞外核苷酸和核苷对神经胶质细胞和神经元细胞的营养作用。
Trends Neurosci. 1996 Jan;19(1):13-8. doi: 10.1016/0166-2236(96)81861-3.
8
Induction of apoptosis in HL-60 human promyelocytic leukemia cells by adenosine A(3) receptor agonists.腺苷A(3)受体激动剂诱导HL-60人早幼粒细胞白血病细胞凋亡
Biochem Biophys Res Commun. 1996 Feb 27;219(3):904-10. doi: 10.1006/bbrc.1996.0331.
9
Adenosine A2b receptors mediate an increase in interleukin (IL)-6 mRNA and IL-6 protein synthesis in human astroglioma cells.腺苷A2b受体介导人星形胶质瘤细胞中白细胞介素（IL）-6信使核糖核酸及IL-6蛋白质合成增加。
J Neurochem. 1996 Apr;66(4):1426-31. doi: 10.1046/j.1471-4159.1996.66041426.x.
10
Adenosine-induced apoptosis in chick embryonic sympathetic neurons: a new physiological role for adenosine.腺苷诱导鸡胚交感神经元凋亡：腺苷的一种新生理作用。
J Physiol. 1995 Oct 1;488 ( Pt 1)(Pt 1):123-38. doi: 10.1113/jphysiol.1995.sp020951.