囊性纤维化幼儿的药物代谢增强。
Enhanced drug metabolism in young children with cystic fibrosis.
作者信息
Parker A C, Pritchard P, Preston T, Smyth R L, Choonara I
机构信息
Institute of Child Health, Alder Hey Children's Hospital, Liverpool.
出版信息
Arch Dis Child. 1997 Sep;77(3):239-41. doi: 10.1136/adc.77.3.239.
Abstract
The effect of cystic fibrosis on caffeine metabolism was studied in young children using the caffeine breath test. Eight children with cystic fibrosis aged 2-6 years and nine age matched controls were studied on a single occasion, and the cumulative percentage of labelled caffeine exhaled as carbon dioxide measured over two hours. This was significantly higher in the patients with cystic fibrosis than in controls, suggesting an increase in the CYP1A2 metabolic pathway in the former. The fact that these were young children with minimal lung and liver disease suggests that enhanced drug metabolism in children with cystic fibrosis is hereditary rather than secondary to lung and liver damage.
摘要
利用咖啡因呼气试验研究了囊性纤维化对幼儿咖啡因代谢的影响。对8名年龄在2至6岁的囊性纤维化患儿和9名年龄匹配的对照儿童进行了单次研究，并测量了两小时内呼出的标记咖啡因作为二氧化碳的累积百分比。囊性纤维化患者的这一比例显著高于对照组，表明前者的CYP1A2代谢途径有所增加。这些是肺部和肝脏疾病轻微的幼儿，这一事实表明，囊性纤维化患儿药物代谢增强是遗传性的，而非继发于肺部和肝脏损伤。
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