采用咖啡因呼气试验评估卡马西平对儿童CYP1A2活性的诱导作用。
Induction of CYP1A2 activity by carbamazepine in children using the caffeine breath test.
作者信息
Parker A C, Pritchard P, Preston T, Choonara I
机构信息
Institute of Child Health, Alder Hey Children's Hospital, Liverpool.
出版信息
Br J Clin Pharmacol. 1998 Feb;45(2):176-8. doi: 10.1046/j.1365-2125.1998.00684.x.
Abstract
AIMS
Carbamazepine is a known enzyme inducer. The aim of this study was to determine whether carbamazepine induces the metabolism of caffeine in children.
METHODS
Children due to receive carbamazepine for epilepsy were recruited into the study. The caffeine breath test was carried out prior to the administration of carbamazepine and after a minimum of 2-3 weeks therapy. Five children were studied and they received 200-600 mg carbamazepine daily.
RESULTS
The mean values of the 2 h cumulative labelled carbon dioxide were 3.47% before and 7.65% during carbamazepine. There was a significant increase in the percentage labelled caffeine exhaled as carbon dioxide during the administration of carbamazepine (Student's paired t-test, P < 0.05).
CONCLUSIONS
The results suggest that carbamazepine induces the metabolism of caffeine by the CYP1A2 pathway in the children studied.
摘要
目的
卡马西平是一种已知的酶诱导剂。本研究的目的是确定卡马西平是否会诱导儿童体内咖啡因的代谢。
方法
招募因癫痫即将接受卡马西平治疗的儿童参与本研究。在服用卡马西平之前以及至少2至3周的治疗后进行咖啡因呼气试验。研究了5名儿童，他们每天服用200 - 600毫克卡马西平。
结果
服用卡马西平前2小时累积标记二氧化碳的平均值为3.47%，服用期间为7.65%。在服用卡马西平期间，呼出的标记为二氧化碳的咖啡因百分比有显著增加（学生配对t检验，P < 0.05）。
结论
结果表明，在本研究的儿童中，卡马西平通过CYP1A2途径诱导咖啡因的代谢。
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